Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer

Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer

Abstract Increasing evidence shows that competitive endogenous RNAs (ceRNAs) can affect the expression of other transcripts by sequestering common microRNAs (miRNAs), and participate in tumourigenesis. As a potent tumour suppressor in colorectal cancer (CRC), SMAD4 is regulated by many miRNAs. Howev...

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Autores principales: Zaozao Wang, Jie Yang, Jiabo Di, Ming Cui, Jiadi Xing, Fan Wu, Wei Wu, Hong Yang, Chenghai Zhang, Zhendan Yao, Nan Zhang, Beihai Jiang, Xiangqian Su
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/2a40c987966d4266861a1cfe6952d3c0
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