Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance

It is expected that plasmids are costly and therefore that selection is required to maintain them within bacterial populations. Here, Wein et al. show that plasmid stability can emerge even in the absence of positive selection and that loss may be determined by transcription-replication conflict.

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Autores principales:	Tanita Wein, Nils F. Hülter, Itzhak Mizrahi, Tal Dagan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a429e74a5e1447aa26da7321d695f52
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spelling	oai:doaj.org-article:2a429e74a5e1447aa26da7321d695f522021-12-02T15:35:54ZEmergence of plasmid stability under non-selective conditions maintains antibiotic resistance10.1038/s41467-019-10600-72041-1723https://doaj.org/article/2a429e74a5e1447aa26da7321d695f522019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10600-7https://doaj.org/toc/2041-1723It is expected that plasmids are costly and therefore that selection is required to maintain them within bacterial populations. Here, Wein et al. show that plasmid stability can emerge even in the absence of positive selection and that loss may be determined by transcription-replication conflict.Tanita WeinNils F. HülterItzhak MizrahiTal DaganNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanita Wein Nils F. Hülter Itzhak Mizrahi Tal Dagan Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
description	It is expected that plasmids are costly and therefore that selection is required to maintain them within bacterial populations. Here, Wein et al. show that plasmid stability can emerge even in the absence of positive selection and that loss may be determined by transcription-replication conflict.
format	article
author	Tanita Wein Nils F. Hülter Itzhak Mizrahi Tal Dagan
author_facet	Tanita Wein Nils F. Hülter Itzhak Mizrahi Tal Dagan
author_sort	Tanita Wein
title	Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
title_short	Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
title_full	Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
title_fullStr	Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
title_full_unstemmed	Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
title_sort	emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2a429e74a5e1447aa26da7321d695f52
work_keys_str_mv	AT tanitawein emergenceofplasmidstabilityundernonselectiveconditionsmaintainsantibioticresistance AT nilsfhulter emergenceofplasmidstabilityundernonselectiveconditionsmaintainsantibioticresistance AT itzhakmizrahi emergenceofplasmidstabilityundernonselectiveconditionsmaintainsantibioticresistance AT taldagan emergenceofplasmidstabilityundernonselectiveconditionsmaintainsantibioticresistance
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Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance

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