Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02
Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation which highlights HLA-B*07:02 as a risk factor.
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2019
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oai:doaj.org-article:2a42af5d272646528b4002af71d710882021-12-02T15:36:20ZGenome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:0210.1038/s41467-019-09117-w2041-1723https://doaj.org/article/2a42af5d272646528b4002af71d710882019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09117-whttps://doaj.org/toc/2041-1723Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation which highlights HLA-B*07:02 as a risk factor.Christos TziotziosChristos PetridisNick DandChrysanthi AinaliJake R. SaklatvalaVenu PullabhatlaAlexandros OnoufriadisRashida PramanikDavid BaudrySang Hyuck LeeKristie WoodLu LiuSeth SeegobinGregory A. MichelottiSu M. LwinEvangelos A. A. ChristouCharles J. CurtisEmanuele de RinaldisAlka SaxenaSusan HolmesMatthew HarriesIoulios PalamarasFiona CunninghamGregory ParkinsManjit KaurPaul FarrantAndrew McDonaghAndrew MessengerJennifer JonesVictoria JolliffeIaisha AliMichael Ardern-JonesCharles MitchellNigel BurrowsRavinder AtkarCedric BanfieldAnton AlexandroffCaroline ChampagneHywel L. CooperSergio Vañó-GalvánAna Maria Molina-RuizNerea Ormaechea PerezGirish K. PatelAbby MacbethMelanie PageAlyson BrydenMegan MowbrayShyamal WahieKeith ArmstrongNicola CookeMark GoodfieldIrene ManDavid de BerkerGiles DunnillAnita TakwaleArchana RaoTee-Wei SiahRodney SinclairMartin S. WadeNcoza C. DlovaJane SetterfieldFiona LewisKapil BhargavaNiall KirkpatrickXavier EstivillCatherine M. StefanatoCarsten FlohrTimothy SpectorFiona M. WattCatherine H. SmithJonathan N. BarkerDavid A. FentonMichael A. SimpsonJohn A. McGrathNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
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DOAJ |
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EN |
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Science Q |
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Science Q Christos Tziotzios Christos Petridis Nick Dand Chrysanthi Ainali Jake R. Saklatvala Venu Pullabhatla Alexandros Onoufriadis Rashida Pramanik David Baudry Sang Hyuck Lee Kristie Wood Lu Liu Seth Seegobin Gregory A. Michelotti Su M. Lwin Evangelos A. A. Christou Charles J. Curtis Emanuele de Rinaldis Alka Saxena Susan Holmes Matthew Harries Ioulios Palamaras Fiona Cunningham Gregory Parkins Manjit Kaur Paul Farrant Andrew McDonagh Andrew Messenger Jennifer Jones Victoria Jolliffe Iaisha Ali Michael Ardern-Jones Charles Mitchell Nigel Burrows Ravinder Atkar Cedric Banfield Anton Alexandroff Caroline Champagne Hywel L. Cooper Sergio Vañó-Galván Ana Maria Molina-Ruiz Nerea Ormaechea Perez Girish K. Patel Abby Macbeth Melanie Page Alyson Bryden Megan Mowbray Shyamal Wahie Keith Armstrong Nicola Cooke Mark Goodfield Irene Man David de Berker Giles Dunnill Anita Takwale Archana Rao Tee-Wei Siah Rodney Sinclair Martin S. Wade Ncoza C. Dlova Jane Setterfield Fiona Lewis Kapil Bhargava Niall Kirkpatrick Xavier Estivill Catherine M. Stefanato Carsten Flohr Timothy Spector Fiona M. Watt Catherine H. Smith Jonathan N. Barker David A. Fenton Michael A. Simpson John A. McGrath Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 |
| description |
Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation which highlights HLA-B*07:02 as a risk factor. |
| format |
article |
| author |
Christos Tziotzios Christos Petridis Nick Dand Chrysanthi Ainali Jake R. Saklatvala Venu Pullabhatla Alexandros Onoufriadis Rashida Pramanik David Baudry Sang Hyuck Lee Kristie Wood Lu Liu Seth Seegobin Gregory A. Michelotti Su M. Lwin Evangelos A. A. Christou Charles J. Curtis Emanuele de Rinaldis Alka Saxena Susan Holmes Matthew Harries Ioulios Palamaras Fiona Cunningham Gregory Parkins Manjit Kaur Paul Farrant Andrew McDonagh Andrew Messenger Jennifer Jones Victoria Jolliffe Iaisha Ali Michael Ardern-Jones Charles Mitchell Nigel Burrows Ravinder Atkar Cedric Banfield Anton Alexandroff Caroline Champagne Hywel L. Cooper Sergio Vañó-Galván Ana Maria Molina-Ruiz Nerea Ormaechea Perez Girish K. Patel Abby Macbeth Melanie Page Alyson Bryden Megan Mowbray Shyamal Wahie Keith Armstrong Nicola Cooke Mark Goodfield Irene Man David de Berker Giles Dunnill Anita Takwale Archana Rao Tee-Wei Siah Rodney Sinclair Martin S. Wade Ncoza C. Dlova Jane Setterfield Fiona Lewis Kapil Bhargava Niall Kirkpatrick Xavier Estivill Catherine M. Stefanato Carsten Flohr Timothy Spector Fiona M. Watt Catherine H. Smith Jonathan N. Barker David A. Fenton Michael A. Simpson John A. McGrath |
| author_facet |
Christos Tziotzios Christos Petridis Nick Dand Chrysanthi Ainali Jake R. Saklatvala Venu Pullabhatla Alexandros Onoufriadis Rashida Pramanik David Baudry Sang Hyuck Lee Kristie Wood Lu Liu Seth Seegobin Gregory A. Michelotti Su M. Lwin Evangelos A. A. Christou Charles J. Curtis Emanuele de Rinaldis Alka Saxena Susan Holmes Matthew Harries Ioulios Palamaras Fiona Cunningham Gregory Parkins Manjit Kaur Paul Farrant Andrew McDonagh Andrew Messenger Jennifer Jones Victoria Jolliffe Iaisha Ali Michael Ardern-Jones Charles Mitchell Nigel Burrows Ravinder Atkar Cedric Banfield Anton Alexandroff Caroline Champagne Hywel L. Cooper Sergio Vañó-Galván Ana Maria Molina-Ruiz Nerea Ormaechea Perez Girish K. Patel Abby Macbeth Melanie Page Alyson Bryden Megan Mowbray Shyamal Wahie Keith Armstrong Nicola Cooke Mark Goodfield Irene Man David de Berker Giles Dunnill Anita Takwale Archana Rao Tee-Wei Siah Rodney Sinclair Martin S. Wade Ncoza C. Dlova Jane Setterfield Fiona Lewis Kapil Bhargava Niall Kirkpatrick Xavier Estivill Catherine M. Stefanato Carsten Flohr Timothy Spector Fiona M. Watt Catherine H. Smith Jonathan N. Barker David A. Fenton Michael A. Simpson John A. McGrath |
| author_sort |
Christos Tziotzios |
| title |
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 |
| title_short |
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 |
| title_full |
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 |
| title_fullStr |
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 |
| title_full_unstemmed |
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 |
| title_sort |
genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including hla-b*07:02 |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2a42af5d272646528b4002af71d71088 |
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