Crystal structures of U6 snRNA-specific terminal uridylyltransferase

After transcription the 3′-end of U6 snRNA is oligo-uridylylated by the terminal uridylyltransferase TUT1. Here the authors present the crystal structure of human TUT1 and give insights into the mechanism of 3′-end uridylylation by the enzyme.

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Detalles Bibliográficos
Autores principales: Seisuke Yamashita, Yuko Takagi, Takashi Nagaike, Kozo Tomita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2a46149eda164db9ab1f82348eeccc5c
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Sumario:After transcription the 3′-end of U6 snRNA is oligo-uridylylated by the terminal uridylyltransferase TUT1. Here the authors present the crystal structure of human TUT1 and give insights into the mechanism of 3′-end uridylylation by the enzyme.