2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring of glucose and lipid metabolism, and further identi...

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Autores principales:	Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian M. MacKay, Sarah-Maria Fendt, Sara Zanivan, Hing Y. Leung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc
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spelling	oai:doaj.org-article:2a468699bc1a4fa682a39a1ff7c055bc2021-12-02T14:58:44Z2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer10.1038/s41467-020-16126-72041-1723https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16126-7https://doaj.org/toc/2041-1723Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring of glucose and lipid metabolism, and further identify a signature associated with resistance to AR inhibition.Arnaud BlommeCatriona A. FordErnest MuiRachana PatelChara NtalaLauren E. JamiesonMélanie PlanqueGrace H. McGregorPaul PeixotoEric HervouetColin NixonMark SaljiLuke GaughanElke MarkertPeter RepiscakDavid SumptonGiovanny Rodriguez BlancoSergio LillaJurre J. KamphorstDuncan GrahamKaren FauldsGillian M. MacKaySarah-Maria FendtSara ZanivanHing Y. LeungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arnaud Blomme Catriona A. Ford Ernest Mui Rachana Patel Chara Ntala Lauren E. Jamieson Mélanie Planque Grace H. McGregor Paul Peixoto Eric Hervouet Colin Nixon Mark Salji Luke Gaughan Elke Markert Peter Repiscak David Sumpton Giovanny Rodriguez Blanco Sergio Lilla Jurre J. Kamphorst Duncan Graham Karen Faulds Gillian M. MacKay Sarah-Maria Fendt Sara Zanivan Hing Y. Leung 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
description	Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring of glucose and lipid metabolism, and further identify a signature associated with resistance to AR inhibition.
format	article
author	Arnaud Blomme Catriona A. Ford Ernest Mui Rachana Patel Chara Ntala Lauren E. Jamieson Mélanie Planque Grace H. McGregor Paul Peixoto Eric Hervouet Colin Nixon Mark Salji Luke Gaughan Elke Markert Peter Repiscak David Sumpton Giovanny Rodriguez Blanco Sergio Lilla Jurre J. Kamphorst Duncan Graham Karen Faulds Gillian M. MacKay Sarah-Maria Fendt Sara Zanivan Hing Y. Leung
author_facet	Arnaud Blomme Catriona A. Ford Ernest Mui Rachana Patel Chara Ntala Lauren E. Jamieson Mélanie Planque Grace H. McGregor Paul Peixoto Eric Hervouet Colin Nixon Mark Salji Luke Gaughan Elke Markert Peter Repiscak David Sumpton Giovanny Rodriguez Blanco Sergio Lilla Jurre J. Kamphorst Duncan Graham Karen Faulds Gillian M. MacKay Sarah-Maria Fendt Sara Zanivan Hing Y. Leung
author_sort	Arnaud Blomme
title	2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
title_short	2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
title_full	2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
title_fullStr	2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
title_full_unstemmed	2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
title_sort	2,4-dienoyl-coa reductase regulates lipid homeostasis in treatment-resistant prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc
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2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

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