GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience

Background. Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is associated with respiratory failure and death in patients with idiopathic inflammatory myositis (IIM) and interstitial lung disease (ILD). This study aimed to investigate clinical parameters associated with mortality in...

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Autores principales:	Chih-Wei Tseng, Kao-Lun Wang, Pin-Kuei Fu, Cheng-Yi Huang, Tsu-Yi Hsieh, Chia-Wei Hsieh, Kuo-Lung Lai, Wei-Ting Hung, Ching-Tsai Lin, Kuo-Tung Tang, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	GAP score CA-153 anti-MDA-5 idiopathic inflammatory myositis interstitial lung disease mortality Medicine R
Acceso en línea:	https://doaj.org/article/2a4687a7196c411aa0ab24eecfedd412
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spelling	oai:doaj.org-article:2a4687a7196c411aa0ab24eecfedd4122021-11-25T18:00:48ZGAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience10.3390/jcm102252412077-0383https://doaj.org/article/2a4687a7196c411aa0ab24eecfedd4122021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5241https://doaj.org/toc/2077-0383Background. Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is associated with respiratory failure and death in patients with idiopathic inflammatory myositis (IIM) and interstitial lung disease (ILD). This study aimed to investigate clinical parameters associated with mortality in anti-MDA-5 antibody-positive patients. Methods. We retrospectively reviewed the clinical and laboratory data, and pulmonary function test results in 55 anti-MDA-5 antibody-positive patients. A comparison was made between the survivors and non-survivors at the 12-month follow-up. Results. A total of 13 patients (23.6%) died within 12 months. Non-survivors had higher GAP scores (gender, age, and physiology score for idiopathic pulmonary fibrosis) (1 vs. 6, <i>p</i> < 0.01) and CA-153 (16.4 vs. 72.9, <i>p</i> < 0.01). In addition, rapid progressive ILD, fever, peak ferritin, leukocyte count, lactate dehydrogenase, CT score, intravenous immunoglobulin, mycophenolic acid, CMV infections, pneumocystis pneumonia, and pneumothorax were significantly associated with increased risks of 1-year mortality, while forced vital capacity, forced expiratory volume in one second, and diffusion capacity for carbon monoxide were correlated with decreased risk of 1-year mortality. Conclusions. Our study results suggest that GAP scores and CA-153 could be prognostic factors for 1-year mortality in anti-MDA-5 antibody-positive patients. A prompt pulmonary function test and CA-153 are essential for these patients to guide further management.Chih-Wei TsengKao-Lun WangPin-Kuei FuCheng-Yi HuangTsu-Yi HsiehChia-Wei HsiehKuo-Lung LaiWei-Ting HungChing-Tsai LinKuo-Tung TangYi-Ming ChenWen-Nan HuangYi-Hsing ChenMDPI AGarticleGAP scoreCA-153anti-MDA-5idiopathic inflammatory myositisinterstitial lung diseasemortalityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5241, p 5241 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GAP score CA-153 anti-MDA-5 idiopathic inflammatory myositis interstitial lung disease mortality Medicine R
spellingShingle	GAP score CA-153 anti-MDA-5 idiopathic inflammatory myositis interstitial lung disease mortality Medicine R Chih-Wei Tseng Kao-Lun Wang Pin-Kuei Fu Cheng-Yi Huang Tsu-Yi Hsieh Chia-Wei Hsieh Kuo-Lung Lai Wei-Ting Hung Ching-Tsai Lin Kuo-Tung Tang Yi-Ming Chen Wen-Nan Huang Yi-Hsing Chen GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience
description	Background. Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is associated with respiratory failure and death in patients with idiopathic inflammatory myositis (IIM) and interstitial lung disease (ILD). This study aimed to investigate clinical parameters associated with mortality in anti-MDA-5 antibody-positive patients. Methods. We retrospectively reviewed the clinical and laboratory data, and pulmonary function test results in 55 anti-MDA-5 antibody-positive patients. A comparison was made between the survivors and non-survivors at the 12-month follow-up. Results. A total of 13 patients (23.6%) died within 12 months. Non-survivors had higher GAP scores (gender, age, and physiology score for idiopathic pulmonary fibrosis) (1 vs. 6, <i>p</i> < 0.01) and CA-153 (16.4 vs. 72.9, <i>p</i> < 0.01). In addition, rapid progressive ILD, fever, peak ferritin, leukocyte count, lactate dehydrogenase, CT score, intravenous immunoglobulin, mycophenolic acid, CMV infections, pneumocystis pneumonia, and pneumothorax were significantly associated with increased risks of 1-year mortality, while forced vital capacity, forced expiratory volume in one second, and diffusion capacity for carbon monoxide were correlated with decreased risk of 1-year mortality. Conclusions. Our study results suggest that GAP scores and CA-153 could be prognostic factors for 1-year mortality in anti-MDA-5 antibody-positive patients. A prompt pulmonary function test and CA-153 are essential for these patients to guide further management.
format	article
author	Chih-Wei Tseng Kao-Lun Wang Pin-Kuei Fu Cheng-Yi Huang Tsu-Yi Hsieh Chia-Wei Hsieh Kuo-Lung Lai Wei-Ting Hung Ching-Tsai Lin Kuo-Tung Tang Yi-Ming Chen Wen-Nan Huang Yi-Hsing Chen
author_facet	Chih-Wei Tseng Kao-Lun Wang Pin-Kuei Fu Cheng-Yi Huang Tsu-Yi Hsieh Chia-Wei Hsieh Kuo-Lung Lai Wei-Ting Hung Ching-Tsai Lin Kuo-Tung Tang Yi-Ming Chen Wen-Nan Huang Yi-Hsing Chen
author_sort	Chih-Wei Tseng
title	GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience
title_short	GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience
title_full	GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience
title_fullStr	GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience
title_full_unstemmed	GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience
title_sort	gap score and ca-153 associated with one-year mortality in anti-mda-5 antibody-positive patients: a real-world experience
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2a4687a7196c411aa0ab24eecfedd412
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GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience

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