Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat

Abstract The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats. α-Klotho (klotho) is an aging-suppressor gene, and overexpression of klotho...

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Autores principales:	M. Morevati, M. L. Mace, S. Egstrand, A. Nordholm, C. Doganli, J. Strand, J. L. Rukov, S. B. Torsetnes, V. Gorbunova, K. Olgaard, E. Lewin
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Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a46cd6fd39e46b79277dde592147138
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spelling	oai:doaj.org-article:2a46cd6fd39e46b79277dde5921471382021-12-02T18:47:08ZExtrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat10.1038/s41598-021-94972-12045-2322https://doaj.org/article/2a46cd6fd39e46b79277dde5921471382021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94972-1https://doaj.org/toc/2045-2322Abstract The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats. α-Klotho (klotho) is an aging-suppressor gene, and overexpression of klotho is associated with extended lifespan in mice. Klotho is predominantly expressed in the kidney. The expression profile of klotho in the NMR has not previously been reported. The present investigation studied the expression of klotho in the kidney of NMR with that of Rattus Norvegicus (RN) and demonstrated that klotho was expressed in the kidney of NMR at the same level as found in RN. Besides, a significant expression of Kl mRNA was found in the liver of NMR, in contrast to RN, where no hepatic expression was detected. The Klotho expression was further confirmed at the protein level. Thus, the results of the present comparative study indicate a differential tissue expression of klotho between different species. Besides its important function in the kidney, Klotho might also be of significance in the liver of NMR. It is suggested that the hepatic extrarenal expression of klotho may function as a further longevity-related factor in supplement to the Klotho in the kidney.M. MorevatiM. L. MaceS. EgstrandA. NordholmC. DoganliJ. StrandJ. L. RukovS. B. TorsetnesV. GorbunovaK. OlgaardE. LewinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Morevati M. L. Mace S. Egstrand A. Nordholm C. Doganli J. Strand J. L. Rukov S. B. Torsetnes V. Gorbunova K. Olgaard E. Lewin Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat
description	Abstract The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats. α-Klotho (klotho) is an aging-suppressor gene, and overexpression of klotho is associated with extended lifespan in mice. Klotho is predominantly expressed in the kidney. The expression profile of klotho in the NMR has not previously been reported. The present investigation studied the expression of klotho in the kidney of NMR with that of Rattus Norvegicus (RN) and demonstrated that klotho was expressed in the kidney of NMR at the same level as found in RN. Besides, a significant expression of Kl mRNA was found in the liver of NMR, in contrast to RN, where no hepatic expression was detected. The Klotho expression was further confirmed at the protein level. Thus, the results of the present comparative study indicate a differential tissue expression of klotho between different species. Besides its important function in the kidney, Klotho might also be of significance in the liver of NMR. It is suggested that the hepatic extrarenal expression of klotho may function as a further longevity-related factor in supplement to the Klotho in the kidney.
format	article
author	M. Morevati M. L. Mace S. Egstrand A. Nordholm C. Doganli J. Strand J. L. Rukov S. B. Torsetnes V. Gorbunova K. Olgaard E. Lewin
author_facet	M. Morevati M. L. Mace S. Egstrand A. Nordholm C. Doganli J. Strand J. L. Rukov S. B. Torsetnes V. Gorbunova K. Olgaard E. Lewin
author_sort	M. Morevati
title	Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat
title_short	Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat
title_full	Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat
title_fullStr	Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat
title_full_unstemmed	Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat
title_sort	extrarenal expression of α-klotho, the kidney related longevity gene, in heterocephalus glaber, the long living naked mole rat
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a46cd6fd39e46b79277dde592147138
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Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat

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