Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.

Infections caused by multidrug-resistant bacteria are a major concern in hospitals. Current infection-control practices legitimately focus on hygiene and appropriate use of antibiotics. However, little is known about the intrinsic abilities of some bacterial strains to cause outbreaks. They can be m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matthieu Domenech de Cellès, Jérôme Salomon, Anne Marinier, Christine Lawrence, Jean-Louis Gaillard, Jean-Louis Herrmann, Didier Guillemot
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a49030355dc484482e359035dc24628
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2a49030355dc484482e359035dc24628
record_format	dspace
spelling	oai:doaj.org-article:2a49030355dc484482e359035dc246282021-11-18T07:04:11ZIdentifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.1932-620310.1371/journal.pone.0045758https://doaj.org/article/2a49030355dc484482e359035dc246282012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029226/?tool=EBIhttps://doaj.org/toc/1932-6203Infections caused by multidrug-resistant bacteria are a major concern in hospitals. Current infection-control practices legitimately focus on hygiene and appropriate use of antibiotics. However, little is known about the intrinsic abilities of some bacterial strains to cause outbreaks. They can be measured at a population level by the pathogen's transmission rate, i.e. the rate at which the pathogen is transmitted from colonized hosts to susceptible hosts, or its reproduction number, counting the number of secondary cases per infected/colonized host. We collected data covering a 20-month surveillance period for carriage of multidrug-resistant Acinetobacter baumannii (MDRAB) in a surgery ward. All isolates were subjected to molecular fingerprinting, and a cluster analysis of profiles was performed to identify clonal groups. We then applied stochastic transmission models to infer transmission rates of MDRAB and each MDRAB clone. Molecular fingerprinting indicated that 3 clonal complexes spread in the ward. A first model, not accounting for different clones, quantified the level of in-ward cross-transmission, with an estimated transmission rate of 0.03/day (95% credible interval [0.012-0.049]) and a single-admission reproduction number of 0.61 [0.30-1.02]. The second model, accounting for different clones, suggested an enhanced transmissibility of clone 3 (transmission rate 0.047/day [0.018-0.091], with a single-admission reproduction number of 0.81 [0.30-1.56]). Clones 1 and 2 had comparable transmission rates (respectively, 0.016 [0.001-0.045], 0.014 [0.001-0.045]). The method used is broadly applicable to other nosocomial pathogens, as long as surveillance data and genotyping information are available. Building on these results, more epidemic clones could be identified, and could lead to follow-up studies dissecting the functional basis for variation in transmissibility of MDRAB lineages.Matthieu Domenech de CellèsJérôme SalomonAnne MarinierChristine LawrenceJean-Louis GaillardJean-Louis HerrmannDidier GuillemotPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45758 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthieu Domenech de Cellès Jérôme Salomon Anne Marinier Christine Lawrence Jean-Louis Gaillard Jean-Louis Herrmann Didier Guillemot Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.
description	Infections caused by multidrug-resistant bacteria are a major concern in hospitals. Current infection-control practices legitimately focus on hygiene and appropriate use of antibiotics. However, little is known about the intrinsic abilities of some bacterial strains to cause outbreaks. They can be measured at a population level by the pathogen's transmission rate, i.e. the rate at which the pathogen is transmitted from colonized hosts to susceptible hosts, or its reproduction number, counting the number of secondary cases per infected/colonized host. We collected data covering a 20-month surveillance period for carriage of multidrug-resistant Acinetobacter baumannii (MDRAB) in a surgery ward. All isolates were subjected to molecular fingerprinting, and a cluster analysis of profiles was performed to identify clonal groups. We then applied stochastic transmission models to infer transmission rates of MDRAB and each MDRAB clone. Molecular fingerprinting indicated that 3 clonal complexes spread in the ward. A first model, not accounting for different clones, quantified the level of in-ward cross-transmission, with an estimated transmission rate of 0.03/day (95% credible interval [0.012-0.049]) and a single-admission reproduction number of 0.61 [0.30-1.02]. The second model, accounting for different clones, suggested an enhanced transmissibility of clone 3 (transmission rate 0.047/day [0.018-0.091], with a single-admission reproduction number of 0.81 [0.30-1.56]). Clones 1 and 2 had comparable transmission rates (respectively, 0.016 [0.001-0.045], 0.014 [0.001-0.045]). The method used is broadly applicable to other nosocomial pathogens, as long as surveillance data and genotyping information are available. Building on these results, more epidemic clones could be identified, and could lead to follow-up studies dissecting the functional basis for variation in transmissibility of MDRAB lineages.
format	article
author	Matthieu Domenech de Cellès Jérôme Salomon Anne Marinier Christine Lawrence Jean-Louis Gaillard Jean-Louis Herrmann Didier Guillemot
author_facet	Matthieu Domenech de Cellès Jérôme Salomon Anne Marinier Christine Lawrence Jean-Louis Gaillard Jean-Louis Herrmann Didier Guillemot
author_sort	Matthieu Domenech de Cellès
title	Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.
title_short	Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.
title_full	Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.
title_fullStr	Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.
title_full_unstemmed	Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.
title_sort	identifying more epidemic clones during a hospital outbreak of multidrug-resistant acinetobacter baumannii.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2a49030355dc484482e359035dc24628
work_keys_str_mv	AT matthieudomenechdecelles identifyingmoreepidemicclonesduringahospitaloutbreakofmultidrugresistantacinetobacterbaumannii AT jeromesalomon identifyingmoreepidemicclonesduringahospitaloutbreakofmultidrugresistantacinetobacterbaumannii AT annemarinier identifyingmoreepidemicclonesduringahospitaloutbreakofmultidrugresistantacinetobacterbaumannii AT christinelawrence identifyingmoreepidemicclonesduringahospitaloutbreakofmultidrugresistantacinetobacterbaumannii AT jeanlouisgaillard identifyingmoreepidemicclonesduringahospitaloutbreakofmultidrugresistantacinetobacterbaumannii AT jeanlouisherrmann identifyingmoreepidemicclonesduringahospitaloutbreakofmultidrugresistantacinetobacterbaumannii AT didierguillemot identifyingmoreepidemicclonesduringahospitaloutbreakofmultidrugresistantacinetobacterbaumannii
_version_	1718423967740461056

Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.

Ejemplares similares