Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine

Hydrogen sulphide (H2S) is a gaseous signalling molecule, which has shown therapeutic value. Here, the authors show that a thioenol metabolite of the antithrombotic drug clopidogrel is an efficient H2S donor and masked thioenols can be linked to existing compounds to develop H2S-releasing agents.

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Autores principales:	Yaoqiu Zhu, Elkin L. Romero, Xiaodong Ren, Angel J. Sanca, Congkuo Du, Cai Liu, Zubair A. Karim, Fatima Z. Alshbool, Fadi T. Khasawneh, Jiang Zhou, Dafang Zhong, Bin Geng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a4a6cb750bb414987d1b5ebe5422517
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spelling	oai:doaj.org-article:2a4a6cb750bb414987d1b5ebe54225172021-12-02T15:34:40ZClopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine10.1038/s41467-018-06373-02041-1723https://doaj.org/article/2a4a6cb750bb414987d1b5ebe54225172018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06373-0https://doaj.org/toc/2041-1723Hydrogen sulphide (H2S) is a gaseous signalling molecule, which has shown therapeutic value. Here, the authors show that a thioenol metabolite of the antithrombotic drug clopidogrel is an efficient H2S donor and masked thioenols can be linked to existing compounds to develop H2S-releasing agents.Yaoqiu ZhuElkin L. RomeroXiaodong RenAngel J. SancaCongkuo DuCai LiuZubair A. KarimFatima Z. AlshboolFadi T. KhasawnehJiang ZhouDafang ZhongBin GengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaoqiu Zhu Elkin L. Romero Xiaodong Ren Angel J. Sanca Congkuo Du Cai Liu Zubair A. Karim Fatima Z. Alshbool Fadi T. Khasawneh Jiang Zhou Dafang Zhong Bin Geng Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine
description	Hydrogen sulphide (H2S) is a gaseous signalling molecule, which has shown therapeutic value. Here, the authors show that a thioenol metabolite of the antithrombotic drug clopidogrel is an efficient H2S donor and masked thioenols can be linked to existing compounds to develop H2S-releasing agents.
format	article
author	Yaoqiu Zhu Elkin L. Romero Xiaodong Ren Angel J. Sanca Congkuo Du Cai Liu Zubair A. Karim Fatima Z. Alshbool Fadi T. Khasawneh Jiang Zhou Dafang Zhong Bin Geng
author_facet	Yaoqiu Zhu Elkin L. Romero Xiaodong Ren Angel J. Sanca Congkuo Du Cai Liu Zubair A. Karim Fatima Z. Alshbool Fadi T. Khasawneh Jiang Zhou Dafang Zhong Bin Geng
author_sort	Yaoqiu Zhu
title	Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine
title_short	Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine
title_full	Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine
title_fullStr	Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine
title_full_unstemmed	Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine
title_sort	clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling h2s biomedicine
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2a4a6cb750bb414987d1b5ebe5422517
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Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine

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