Structural basis for conductance through TRIC cation channels

Structural basis for conductance through TRIC cation channels

Trimeric intracellular cation channels (TRICs) elicit K+ currents to counteract luminal negative potential during Ca2+release from intracellular stores. Here the authors present structures of prokaryotic TRICs in their open and closed states, obtaining molecular insight into TRICs’ function.

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Auteurs principaux: Min Su, Feng Gao, Qi Yuan, Yang Mao, De-lin Li, Youzhong Guo, Cheng Yang, Xiao-hui Wang, Renato Bruni, Brian Kloss, Hong Zhao, Yang Zeng, Fa-ben Zhang, Andrew R Marks, Wayne A Hendrickson, Yu-hang Chen
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/2a4a9abd619e4a199b9d5f94dba0f20f
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Résumé:Trimeric intracellular cation channels (TRICs) elicit K+ currents to counteract luminal negative potential during Ca2+release from intracellular stores. Here the authors present structures of prokaryotic TRICs in their open and closed states, obtaining molecular insight into TRICs’ function.

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