Fluorescence properties of curcumin-loaded nanoparticles for cell tracking

Bassam Felipe Mogharbel,1 Julio Cesar Francisco,1 Ana Carolina Irioda,1 Dilcele Silva Moreira Dziedzic,1 Priscila Elias Ferreira,1 Daiany de Souza,1 Carolina Maria Costa de Oliveira Souza,1 Nelson Bergonse Neto,2 Luiz Cesar Guarita-Souza,2 Celia Regina Cavichiolo Franco,3 Celso Vataru Nakamura,4 Van...

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Autores principales:	Mogharbel BF, Francisco JC, Irioda AC, Dziedzic DSM, Ferreira PE, Souza D, Souza CMCO, Bergonse Neto N, Guarita-Souza LC, Franco CRC, Nakamura CV, Kaplum V, Mazzarino L, Lemos-Senna E, Borsali R, Soto PA, Setton-Avruj P, Abdelwahid E, Carvalho KA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	mesenchymal stem cells transplantation cell marking myocardium infarction sciatic nerve crush. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2a4f3c6e8a804a4ab61f6aa3b979e1fd
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spelling	oai:doaj.org-article:2a4f3c6e8a804a4ab61f6aa3b979e1fd2021-12-02T07:35:13ZFluorescence properties of curcumin-loaded nanoparticles for cell tracking1178-2013https://doaj.org/article/2a4f3c6e8a804a4ab61f6aa3b979e1fd2018-09-01T00:00:00Zhttps://www.dovepress.com/fluorescence-properties-of-curcumin-loaded-nanoparticles-for-cell-trac-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bassam Felipe Mogharbel,1 Julio Cesar Francisco,1 Ana Carolina Irioda,1 Dilcele Silva Moreira Dziedzic,1 Priscila Elias Ferreira,1 Daiany de Souza,1 Carolina Maria Costa de Oliveira Souza,1 Nelson Bergonse Neto,2 Luiz Cesar Guarita-Souza,2 Celia Regina Cavichiolo Franco,3 Celso Vataru Nakamura,4 Vanessa Kaplum,4 Letícia Mazzarino,5 Elenara Lemos-Senna,6 Redouane Borsali,7 Paula A Soto,8 Patricia Setton-Avruj,8 Eltyeb Abdelwahid,9 Katherine Athayde Teixeira de Carvalho1 1Cell Therapy and Biotechnology in Regenerative Medicine Department, Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research and Pequeno Príncipe Faculty, Curitiba, Paraná, Brazil; 2Institute of Biological and Health Sciences, Pontifical Catholic University of Paraná (PUCPR), Centro de Ciências Biológicas e da Saúde (CCBS), Curitiba, Brazil; 3Cell Biology Department, Federal University of Paraná, Curitiba, Paraná, Brazil; 4Department of Pharmaceutical Sciences, Universidade Estadual de Maringá, Maringá, Paraná, Brazil; 5Department of Pharmaceutical Sciences, NanoBioMat Laboratory, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; 6Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; 7Centre de Recherches sur les Macromolécules Végétales (CERMAV), Centre National de la Recherche Scientifique (CNRS), University Grenoble Alpes, F-38000, Grenoble, France; 8Instituto de Química y Físicoquímica Biológica (IQUIFIB), Departament of Química Biológica, Facultad de Farmacia y Bíoquímica, Universidad de Buenos Aires (UBA) Consejo nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentine; 9Feinberg School of Medicine, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, Il, USA Background: Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems. Materials and methods: In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done. Results: Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking. Conclusion: This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies. Keywords: mesenchymal stem cells, transplantation, cell marking, myocardium infarction, sciatic nerve crushMogharbel BFFrancisco JCIrioda ACDziedzic DSMFerreira PESouza DSouza CMCOBergonse Neto NGuarita-Souza LCFranco CRCNakamura CVKaplum VMazzarino LLemos-Senna EBorsali RSoto PASetton-Avruj PAbdelwahid ECarvalho KADove Medical Pressarticlemesenchymal stem cellstransplantationcell markingmyocardium infarctionsciatic nerve crush.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5823-5836 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stem cells transplantation cell marking myocardium infarction sciatic nerve crush. Medicine (General) R5-920
spellingShingle	mesenchymal stem cells transplantation cell marking myocardium infarction sciatic nerve crush. Medicine (General) R5-920 Mogharbel BF Francisco JC Irioda AC Dziedzic DSM Ferreira PE Souza D Souza CMCO Bergonse Neto N Guarita-Souza LC Franco CRC Nakamura CV Kaplum V Mazzarino L Lemos-Senna E Borsali R Soto PA Setton-Avruj P Abdelwahid E Carvalho KA Fluorescence properties of curcumin-loaded nanoparticles for cell tracking
description	Bassam Felipe Mogharbel,1 Julio Cesar Francisco,1 Ana Carolina Irioda,1 Dilcele Silva Moreira Dziedzic,1 Priscila Elias Ferreira,1 Daiany de Souza,1 Carolina Maria Costa de Oliveira Souza,1 Nelson Bergonse Neto,2 Luiz Cesar Guarita-Souza,2 Celia Regina Cavichiolo Franco,3 Celso Vataru Nakamura,4 Vanessa Kaplum,4 Letícia Mazzarino,5 Elenara Lemos-Senna,6 Redouane Borsali,7 Paula A Soto,8 Patricia Setton-Avruj,8 Eltyeb Abdelwahid,9 Katherine Athayde Teixeira de Carvalho1 1Cell Therapy and Biotechnology in Regenerative Medicine Department, Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research and Pequeno Príncipe Faculty, Curitiba, Paraná, Brazil; 2Institute of Biological and Health Sciences, Pontifical Catholic University of Paraná (PUCPR), Centro de Ciências Biológicas e da Saúde (CCBS), Curitiba, Brazil; 3Cell Biology Department, Federal University of Paraná, Curitiba, Paraná, Brazil; 4Department of Pharmaceutical Sciences, Universidade Estadual de Maringá, Maringá, Paraná, Brazil; 5Department of Pharmaceutical Sciences, NanoBioMat Laboratory, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; 6Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; 7Centre de Recherches sur les Macromolécules Végétales (CERMAV), Centre National de la Recherche Scientifique (CNRS), University Grenoble Alpes, F-38000, Grenoble, France; 8Instituto de Química y Físicoquímica Biológica (IQUIFIB), Departament of Química Biológica, Facultad de Farmacia y Bíoquímica, Universidad de Buenos Aires (UBA) Consejo nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentine; 9Feinberg School of Medicine, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, Il, USA Background: Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems. Materials and methods: In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done. Results: Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking. Conclusion: This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies. Keywords: mesenchymal stem cells, transplantation, cell marking, myocardium infarction, sciatic nerve crush
format	article
author	Mogharbel BF Francisco JC Irioda AC Dziedzic DSM Ferreira PE Souza D Souza CMCO Bergonse Neto N Guarita-Souza LC Franco CRC Nakamura CV Kaplum V Mazzarino L Lemos-Senna E Borsali R Soto PA Setton-Avruj P Abdelwahid E Carvalho KA
author_facet	Mogharbel BF Francisco JC Irioda AC Dziedzic DSM Ferreira PE Souza D Souza CMCO Bergonse Neto N Guarita-Souza LC Franco CRC Nakamura CV Kaplum V Mazzarino L Lemos-Senna E Borsali R Soto PA Setton-Avruj P Abdelwahid E Carvalho KA
author_sort	Mogharbel BF
title	Fluorescence properties of curcumin-loaded nanoparticles for cell tracking
title_short	Fluorescence properties of curcumin-loaded nanoparticles for cell tracking
title_full	Fluorescence properties of curcumin-loaded nanoparticles for cell tracking
title_fullStr	Fluorescence properties of curcumin-loaded nanoparticles for cell tracking
title_full_unstemmed	Fluorescence properties of curcumin-loaded nanoparticles for cell tracking
title_sort	fluorescence properties of curcumin-loaded nanoparticles for cell tracking
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/2a4f3c6e8a804a4ab61f6aa3b979e1fd
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Fluorescence properties of curcumin-loaded nanoparticles for cell tracking

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