Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels

Abstract It has been observed that there is a lower Parkinson’s disease (PD) incidence in tobacco users. Nicotine is a cholinergic agonist and is the principal psychoactive compound in tobacco linked to cigarette addiction. Different studies have shown that nicotine has beneficial effects on sporadi...

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Autores principales:	Angel Carvajal-Oliveros, Carmen Domínguez-Baleón, Rafaella V. Zárate, Jorge M. Campusano, Verónica Narváez-Padilla, Enrique Reynaud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a4fbd441f2c45dd98e95e3ab2c8c088
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spelling	oai:doaj.org-article:2a4fbd441f2c45dd98e95e3ab2c8c0882021-12-02T14:41:56ZNicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels10.1038/s41598-021-88910-42045-2322https://doaj.org/article/2a4fbd441f2c45dd98e95e3ab2c8c0882021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88910-4https://doaj.org/toc/2045-2322Abstract It has been observed that there is a lower Parkinson’s disease (PD) incidence in tobacco users. Nicotine is a cholinergic agonist and is the principal psychoactive compound in tobacco linked to cigarette addiction. Different studies have shown that nicotine has beneficial effects on sporadic and genetic models of PD. In this work we evaluate nicotine’s protective effect in a Drosophila melanogaster model for PD where Synphilin-1 (Sph-1) is expressed in dopaminergic neurons. Nicotine has a moderate effect on dopaminergic neuron survival that becomes more evident as flies age. Nicotine is beneficial on fly survival and motility increasing tyrosine hydroxylase and dopamine levels, suggesting that cholinergic agonists may promote survival and metabolic function of the dopaminergic neurons that express Sph-1. The Sph-1 expressing fly is a good model for the study of early-onset phenotypes such as olfaction loss one of the main non-motor symptom related to PD. Our data suggest that nicotine is an interesting therapeutic molecule whose properties should be explored in future research on the phenotypic modulators of the disease and for the development of new treatments.Angel Carvajal-OliverosCarmen Domínguez-BaleónRafaella V. ZárateJorge M. CampusanoVerónica Narváez-PadillaEnrique ReynaudNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angel Carvajal-Oliveros Carmen Domínguez-Baleón Rafaella V. Zárate Jorge M. Campusano Verónica Narváez-Padilla Enrique Reynaud Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
description	Abstract It has been observed that there is a lower Parkinson’s disease (PD) incidence in tobacco users. Nicotine is a cholinergic agonist and is the principal psychoactive compound in tobacco linked to cigarette addiction. Different studies have shown that nicotine has beneficial effects on sporadic and genetic models of PD. In this work we evaluate nicotine’s protective effect in a Drosophila melanogaster model for PD where Synphilin-1 (Sph-1) is expressed in dopaminergic neurons. Nicotine has a moderate effect on dopaminergic neuron survival that becomes more evident as flies age. Nicotine is beneficial on fly survival and motility increasing tyrosine hydroxylase and dopamine levels, suggesting that cholinergic agonists may promote survival and metabolic function of the dopaminergic neurons that express Sph-1. The Sph-1 expressing fly is a good model for the study of early-onset phenotypes such as olfaction loss one of the main non-motor symptom related to PD. Our data suggest that nicotine is an interesting therapeutic molecule whose properties should be explored in future research on the phenotypic modulators of the disease and for the development of new treatments.
format	article
author	Angel Carvajal-Oliveros Carmen Domínguez-Baleón Rafaella V. Zárate Jorge M. Campusano Verónica Narváez-Padilla Enrique Reynaud
author_facet	Angel Carvajal-Oliveros Carmen Domínguez-Baleón Rafaella V. Zárate Jorge M. Campusano Verónica Narváez-Padilla Enrique Reynaud
author_sort	Angel Carvajal-Oliveros
title	Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
title_short	Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
title_full	Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
title_fullStr	Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
title_full_unstemmed	Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
title_sort	nicotine suppresses parkinson’s disease like phenotypes induced by synphilin-1 overexpression in drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a4fbd441f2c45dd98e95e3ab2c8c088
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Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels

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