The bioenergetic status relates to dopamine neuron loss in familial PD with PINK1 mutations.

Mutations in the PINK1 gene cause autosomal recessive familial Parkinson's disease (PD). The gene encodes a mitochondrial protein kinase that plays an important role in maintaining mitochondrial function and integrity. However, the pathophysiological link between mutation-related bioenergetic d...

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Autores principales: Rüediger Hilker, Ulrich Pilatus, Carsten Eggers, Johann Hagenah, Julia Roggendorf, Simon Baudrexel, Johannes C Klein, Bernd Neumaier, Gereon R Fink, Helmuth Steinmetz, Christine Klein, Elke Hattingen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/2a51e3e1ab3346638b11aeb6aeb35cb0
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