Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action

Theresa Gillis, Megan Crane, Carly Hinkle, Nathan Wei Arthritis Treatment Center, Frederick, MD, USA Objective: Many types of treatment are available for patients with rheumatoid arthritis (RA), however, some patients fail to achieve remission. This report aims to determin...

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Autores principales:	Gillis T, Crane M, Hinkle C, Wei N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Refractory rheumatoid arthritis rheumatoid arthritis adrenocorticotropic hormone repository corticotropin injection Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/2a53c5322b2446e79e3ff820d1709e0b
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spelling	oai:doaj.org-article:2a53c5322b2446e79e3ff820d1709e0b2021-12-02T08:24:19ZRepository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action1179-156Xhttps://doaj.org/article/2a53c5322b2446e79e3ff820d1709e0b2017-07-01T00:00:00Zhttps://www.dovepress.com/repository-corticotropin-injection-as-adjunctive-therapy-in-patients-w-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XTheresa Gillis, Megan Crane, Carly Hinkle, Nathan Wei Arthritis Treatment Center, Frederick, MD, USA Objective: Many types of treatment are available for patients with rheumatoid arthritis (RA), however, some patients fail to achieve remission. This report aims to determine the safety and efficacy of using repository corticotropin injection (RCI) as an adjunctive therapy in patients with RA refractory to at least three therapeutics with different mechanisms of action. Method: In this open-label, interventional, single-group study, patients received 80 U RCI twice weekly via subcutaneous injection over 12 weeks. Changes in the Ritchie–Camp Articular Index and health assessment questionnaire scores were monitored for changes from baseline measures. Results: Eight patients were enrolled and consisted of seven females and one male with an average age of 64.6 years and disease duration of 20.9 years. Use of RCI resulted in significant improvement in swollen and tender joint counts. The disease activity score 28 and the physician and patient visual analog scale scores were significantly reduced at treatment week 12. The reduction in health assessment questionnaire scores did not reach statistical significance after RCI treatment. Once RCI therapy was discontinued, all improvements in disease activity score 28, physician and patient visual analog scale, and tender and swollen joint counts achieved during treatment were lost by the week 16 follow-up visit. Conclusion: While larger clinical trials are necessary to further confirm the efficacy of RCI in patients with refractory RA, the response of patients with refractory RA in this study suggests that RCI can be an effective add-on therapy for patients who have exhausted several classes of treatments. Furthermore, this study suggests that RCI has an alternative mode of action, compared to other available antirheumatic drugs. Keywords: refractory rheumatoid arthritis, rheumatoid arthritis, adrenocorticotropic hormone, repository corticotropin injectionGillis TCrane MHinkle CWei NDove Medical PressarticleRefractory rheumatoid arthritisrheumatoid arthritisadrenocorticotropic hormonerepository corticotropin injectionDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 9, Pp 131-138 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Refractory rheumatoid arthritis rheumatoid arthritis adrenocorticotropic hormone repository corticotropin injection Diseases of the musculoskeletal system RC925-935
spellingShingle	Refractory rheumatoid arthritis rheumatoid arthritis adrenocorticotropic hormone repository corticotropin injection Diseases of the musculoskeletal system RC925-935 Gillis T Crane M Hinkle C Wei N Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
description	Theresa Gillis, Megan Crane, Carly Hinkle, Nathan Wei Arthritis Treatment Center, Frederick, MD, USA Objective: Many types of treatment are available for patients with rheumatoid arthritis (RA), however, some patients fail to achieve remission. This report aims to determine the safety and efficacy of using repository corticotropin injection (RCI) as an adjunctive therapy in patients with RA refractory to at least three therapeutics with different mechanisms of action. Method: In this open-label, interventional, single-group study, patients received 80 U RCI twice weekly via subcutaneous injection over 12 weeks. Changes in the Ritchie–Camp Articular Index and health assessment questionnaire scores were monitored for changes from baseline measures. Results: Eight patients were enrolled and consisted of seven females and one male with an average age of 64.6 years and disease duration of 20.9 years. Use of RCI resulted in significant improvement in swollen and tender joint counts. The disease activity score 28 and the physician and patient visual analog scale scores were significantly reduced at treatment week 12. The reduction in health assessment questionnaire scores did not reach statistical significance after RCI treatment. Once RCI therapy was discontinued, all improvements in disease activity score 28, physician and patient visual analog scale, and tender and swollen joint counts achieved during treatment were lost by the week 16 follow-up visit. Conclusion: While larger clinical trials are necessary to further confirm the efficacy of RCI in patients with refractory RA, the response of patients with refractory RA in this study suggests that RCI can be an effective add-on therapy for patients who have exhausted several classes of treatments. Furthermore, this study suggests that RCI has an alternative mode of action, compared to other available antirheumatic drugs. Keywords: refractory rheumatoid arthritis, rheumatoid arthritis, adrenocorticotropic hormone, repository corticotropin injection
format	article
author	Gillis T Crane M Hinkle C Wei N
author_facet	Gillis T Crane M Hinkle C Wei N
author_sort	Gillis T
title	Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
title_short	Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
title_full	Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
title_fullStr	Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
title_full_unstemmed	Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
title_sort	repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2a53c5322b2446e79e3ff820d1709e0b
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Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action

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