Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 cancer types on a single clinical ICB trial and...

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Autores principales: S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2a55653c8f4a4ed888f461e4bdb5696f
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spelling oai:doaj.org-article:2a55653c8f4a4ed888f461e4bdb5696f2021-12-02T18:53:20ZPan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity10.1038/s41467-021-25432-72041-1723https://doaj.org/article/2a55653c8f4a4ed888f461e4bdb5696f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25432-7https://doaj.org/toc/2041-1723Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 cancer types on a single clinical ICB trial and identify tumour microenvironment features associated with response.S. Y. Cindy YangScott C. LienBen X. WangDerek L. ClouthierYoustina HannaIulia CirlanKelsey ZhuJeffrey P. BruceSamah El GhamrasniMarco A. J. IafollaMarc OlivaAaron R. HansenAnna SpreaficoPhilippe L. BedardStephanie LheureuxAlbiruni RazakVanessa SpeersHal K. BermanAlexey AleshinBenjamin Haibe-KainsDavid G. BrooksTracy L. McGahaMarcus O. ButlerScott V. BratmanPamela S. OhashiLillian L. SiuTrevor J. PughNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
S. Y. Cindy Yang
Scott C. Lien
Ben X. Wang
Derek L. Clouthier
Youstina Hanna
Iulia Cirlan
Kelsey Zhu
Jeffrey P. Bruce
Samah El Ghamrasni
Marco A. J. Iafolla
Marc Oliva
Aaron R. Hansen
Anna Spreafico
Philippe L. Bedard
Stephanie Lheureux
Albiruni Razak
Vanessa Speers
Hal K. Berman
Alexey Aleshin
Benjamin Haibe-Kains
David G. Brooks
Tracy L. McGaha
Marcus O. Butler
Scott V. Bratman
Pamela S. Ohashi
Lillian L. Siu
Trevor J. Pugh
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
description Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 cancer types on a single clinical ICB trial and identify tumour microenvironment features associated with response.
format article
author S. Y. Cindy Yang
Scott C. Lien
Ben X. Wang
Derek L. Clouthier
Youstina Hanna
Iulia Cirlan
Kelsey Zhu
Jeffrey P. Bruce
Samah El Ghamrasni
Marco A. J. Iafolla
Marc Oliva
Aaron R. Hansen
Anna Spreafico
Philippe L. Bedard
Stephanie Lheureux
Albiruni Razak
Vanessa Speers
Hal K. Berman
Alexey Aleshin
Benjamin Haibe-Kains
David G. Brooks
Tracy L. McGaha
Marcus O. Butler
Scott V. Bratman
Pamela S. Ohashi
Lillian L. Siu
Trevor J. Pugh
author_facet S. Y. Cindy Yang
Scott C. Lien
Ben X. Wang
Derek L. Clouthier
Youstina Hanna
Iulia Cirlan
Kelsey Zhu
Jeffrey P. Bruce
Samah El Ghamrasni
Marco A. J. Iafolla
Marc Oliva
Aaron R. Hansen
Anna Spreafico
Philippe L. Bedard
Stephanie Lheureux
Albiruni Razak
Vanessa Speers
Hal K. Berman
Alexey Aleshin
Benjamin Haibe-Kains
David G. Brooks
Tracy L. McGaha
Marcus O. Butler
Scott V. Bratman
Pamela S. Ohashi
Lillian L. Siu
Trevor J. Pugh
author_sort S. Y. Cindy Yang
title Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
title_short Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
title_full Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
title_fullStr Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
title_full_unstemmed Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
title_sort pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2a55653c8f4a4ed888f461e4bdb5696f
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