Scenarios for 3D printing of personalized medicines - A case study

Background: 3D printing is a promising new technology for medicines' production. It employs additive manufacturing techniques, and is ideal for producing personalized medicines (e.g., patient-tailored dose, dosage form, drug release kinetics). Objective: To investigate how 3D printing technolog...

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Autores principales:	Netta Beer, Ingrid Hegger, Susanne Kaae, Marie Louise De Bruin, Natalja Genina, Teresa Leonardo Alves, Joelle Hoebert, Sofia Kälvemark Sporrong
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Personalized medicine Compounding Magistral medicines 3D printing Societal impact Qualitative interviews Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/2a577cd7760b444fa9ba220b6311a539
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spelling	oai:doaj.org-article:2a577cd7760b444fa9ba220b6311a5392021-11-28T04:39:57ZScenarios for 3D printing of personalized medicines - A case study2667-276610.1016/j.rcsop.2021.100073https://doaj.org/article/2a577cd7760b444fa9ba220b6311a5392021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667276621000731https://doaj.org/toc/2667-2766Background: 3D printing is a promising new technology for medicines' production. It employs additive manufacturing techniques, and is ideal for producing personalized medicines (e.g., patient-tailored dose, dosage form, drug release kinetics). Objective: To investigate how 3D printing technologies can be implemented in a European pharmaceutical system, by suggesting different scenarios and assessing aspects that could affect its implementation. Method: Qualitative, semi-structured interviews were conducted with key stakeholders (e.g., from ministry, authorities, research organizations, pharmacies) in the Netherlands to elicit perspectives on 3D printing of personalized medicines. The Netherlands were chosen since it has a strong tradition in compounding. Five general scenarios were investigated: placing the 3D printers in industry, community pharmacies, hospital pharmacies, compounding facilities, and in patients' homes. Content analysis was used, building on verbatim transcripts. Results: Fifteen stakeholders were interviewed. Regulatory, economic, ethical and organizational challenges were identified to varying degrees in the different scenarios. The industry and home scenarios were associated with the most challenges, hospital pharmacies and compounding facilities with the least. Other important aspects identified were the role of community pharmacies, and who should design the tablets to be printed. Conclusion: All potential scenarios for 3D printing of personalized medicines include challenges. These should be taken into account when pursuing the use of 3D printing of medicine.Netta BeerIngrid HeggerSusanne KaaeMarie Louise De BruinNatalja GeninaTeresa Leonardo AlvesJoelle HoebertSofia Kälvemark SporrongElsevierarticlePersonalized medicineCompoundingMagistral medicines3D printingSocietal impactQualitative interviewsPharmacy and materia medicaRS1-441ENExploratory Research in Clinical and Social Pharmacy, Vol 4, Iss , Pp 100073- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Personalized medicine Compounding Magistral medicines 3D printing Societal impact Qualitative interviews Pharmacy and materia medica RS1-441
spellingShingle	Personalized medicine Compounding Magistral medicines 3D printing Societal impact Qualitative interviews Pharmacy and materia medica RS1-441 Netta Beer Ingrid Hegger Susanne Kaae Marie Louise De Bruin Natalja Genina Teresa Leonardo Alves Joelle Hoebert Sofia Kälvemark Sporrong Scenarios for 3D printing of personalized medicines - A case study
description	Background: 3D printing is a promising new technology for medicines' production. It employs additive manufacturing techniques, and is ideal for producing personalized medicines (e.g., patient-tailored dose, dosage form, drug release kinetics). Objective: To investigate how 3D printing technologies can be implemented in a European pharmaceutical system, by suggesting different scenarios and assessing aspects that could affect its implementation. Method: Qualitative, semi-structured interviews were conducted with key stakeholders (e.g., from ministry, authorities, research organizations, pharmacies) in the Netherlands to elicit perspectives on 3D printing of personalized medicines. The Netherlands were chosen since it has a strong tradition in compounding. Five general scenarios were investigated: placing the 3D printers in industry, community pharmacies, hospital pharmacies, compounding facilities, and in patients' homes. Content analysis was used, building on verbatim transcripts. Results: Fifteen stakeholders were interviewed. Regulatory, economic, ethical and organizational challenges were identified to varying degrees in the different scenarios. The industry and home scenarios were associated with the most challenges, hospital pharmacies and compounding facilities with the least. Other important aspects identified were the role of community pharmacies, and who should design the tablets to be printed. Conclusion: All potential scenarios for 3D printing of personalized medicines include challenges. These should be taken into account when pursuing the use of 3D printing of medicine.
format	article
author	Netta Beer Ingrid Hegger Susanne Kaae Marie Louise De Bruin Natalja Genina Teresa Leonardo Alves Joelle Hoebert Sofia Kälvemark Sporrong
author_facet	Netta Beer Ingrid Hegger Susanne Kaae Marie Louise De Bruin Natalja Genina Teresa Leonardo Alves Joelle Hoebert Sofia Kälvemark Sporrong
author_sort	Netta Beer
title	Scenarios for 3D printing of personalized medicines - A case study
title_short	Scenarios for 3D printing of personalized medicines - A case study
title_full	Scenarios for 3D printing of personalized medicines - A case study
title_fullStr	Scenarios for 3D printing of personalized medicines - A case study
title_full_unstemmed	Scenarios for 3D printing of personalized medicines - A case study
title_sort	scenarios for 3d printing of personalized medicines - a case study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2a577cd7760b444fa9ba220b6311a539
work_keys_str_mv	AT nettabeer scenariosfor3dprintingofpersonalizedmedicinesacasestudy AT ingridhegger scenariosfor3dprintingofpersonalizedmedicinesacasestudy AT susannekaae scenariosfor3dprintingofpersonalizedmedicinesacasestudy AT marielouisedebruin scenariosfor3dprintingofpersonalizedmedicinesacasestudy AT nataljagenina scenariosfor3dprintingofpersonalizedmedicinesacasestudy AT teresaleonardoalves scenariosfor3dprintingofpersonalizedmedicinesacasestudy AT joellehoebert scenariosfor3dprintingofpersonalizedmedicinesacasestudy AT sofiakalvemarksporrong scenariosfor3dprintingofpersonalizedmedicinesacasestudy
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Scenarios for 3D printing of personalized medicines - A case study

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