Age‐related decline in cortical inhibitory tone strengthens motor memory

Ageing disrupts the finely tuned excitation/inhibition balance (E:I) across cortex via a natural decline in inhibitory tone (γ-amino butyric acid, GABA), causing functional decrements. However, in young adults, experimentally lowering GABA in sensorimotor cortex enhances a specific domain of sensori...

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Autores principales:	Pierre Petitet, Gershon Spitz, Uzay E. Emir, Heidi Johansen-Berg, Jacinta O’Shea
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Sensorimotor adaptation Ageing Excitation:inhibition ratio Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/2a57a10c020847e8b95584e578805568
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spelling	oai:doaj.org-article:2a57a10c020847e8b95584e5788055682021-11-04T04:26:44ZAge‐related decline in cortical inhibitory tone strengthens motor memory1095-957210.1016/j.neuroimage.2021.118681https://doaj.org/article/2a57a10c020847e8b95584e5788055682021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S105381192100954Xhttps://doaj.org/toc/1095-9572Ageing disrupts the finely tuned excitation/inhibition balance (E:I) across cortex via a natural decline in inhibitory tone (γ-amino butyric acid, GABA), causing functional decrements. However, in young adults, experimentally lowering GABA in sensorimotor cortex enhances a specific domain of sensorimotor function: adaptation memory. Here, we tested the hypothesis that as sensorimotor cortical GABA declines naturally with age, adaptation memory would increase, and the former would explain the latter. Results confirmed this prediction. To probe causality, we used brain stimulation to further lower sensorimotor cortical GABA during adaptation. Across individuals, how stimulation changed memory depended on sensorimotor cortical E:I. In those with low E:I, stimulation increased memory; in those with high E:I stimulation reduced memory. Thus, we identified a form of motor memory that is naturally strengthened by age, depends causally on sensorimotor cortex neurochemistry, and may be a potent target for motor skill preservation strategies in healthy ageing and neurorehabilitation.Pierre PetitetGershon SpitzUzay E. EmirHeidi Johansen-BergJacinta O’SheaElsevierarticleSensorimotor adaptationAgeingExcitation:inhibition ratioNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118681- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sensorimotor adaptation Ageing Excitation:inhibition ratio Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Sensorimotor adaptation Ageing Excitation:inhibition ratio Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Pierre Petitet Gershon Spitz Uzay E. Emir Heidi Johansen-Berg Jacinta O’Shea Age‐related decline in cortical inhibitory tone strengthens motor memory
description	Ageing disrupts the finely tuned excitation/inhibition balance (E:I) across cortex via a natural decline in inhibitory tone (γ-amino butyric acid, GABA), causing functional decrements. However, in young adults, experimentally lowering GABA in sensorimotor cortex enhances a specific domain of sensorimotor function: adaptation memory. Here, we tested the hypothesis that as sensorimotor cortical GABA declines naturally with age, adaptation memory would increase, and the former would explain the latter. Results confirmed this prediction. To probe causality, we used brain stimulation to further lower sensorimotor cortical GABA during adaptation. Across individuals, how stimulation changed memory depended on sensorimotor cortical E:I. In those with low E:I, stimulation increased memory; in those with high E:I stimulation reduced memory. Thus, we identified a form of motor memory that is naturally strengthened by age, depends causally on sensorimotor cortex neurochemistry, and may be a potent target for motor skill preservation strategies in healthy ageing and neurorehabilitation.
format	article
author	Pierre Petitet Gershon Spitz Uzay E. Emir Heidi Johansen-Berg Jacinta O’Shea
author_facet	Pierre Petitet Gershon Spitz Uzay E. Emir Heidi Johansen-Berg Jacinta O’Shea
author_sort	Pierre Petitet
title	Age‐related decline in cortical inhibitory tone strengthens motor memory
title_short	Age‐related decline in cortical inhibitory tone strengthens motor memory
title_full	Age‐related decline in cortical inhibitory tone strengthens motor memory
title_fullStr	Age‐related decline in cortical inhibitory tone strengthens motor memory
title_full_unstemmed	Age‐related decline in cortical inhibitory tone strengthens motor memory
title_sort	age‐related decline in cortical inhibitory tone strengthens motor memory
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2a57a10c020847e8b95584e578805568
work_keys_str_mv	AT pierrepetitet agerelateddeclineincorticalinhibitorytonestrengthensmotormemory AT gershonspitz agerelateddeclineincorticalinhibitorytonestrengthensmotormemory AT uzayeemir agerelateddeclineincorticalinhibitorytonestrengthensmotormemory AT heidijohansenberg agerelateddeclineincorticalinhibitorytonestrengthensmotormemory AT jacintaoshea agerelateddeclineincorticalinhibitorytonestrengthensmotormemory
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Age‐related decline in cortical inhibitory tone strengthens motor memory

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