Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.

Peach tree allergens are present in fruit, pollen, branches, and leaves, and can induce systemic, respiratory, cutaneous, and gastrointestinal symptoms. We studied the capacity of peach fruit/Pru p 1, Pru p 3, Pru p 4, Pru p 7 and peach pollen/Pru p 9 for inducing symptoms following oral or respirat...

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Autores principales:	Maria Luisa Somoza, Natalia Pérez-Sánchez, Laura Victorio-Puche, Laura Martín-Pedraza, Angel Esteban Rodríguez, Natalia Blanca-López, Eva Abel Fernández González, María Ruano-Zaragoza, Ana Prieto-Moreno Pfeifer, Enrique Fernández Caldas, Miriam Morán Morales, Francisco Javier Fernández Sánchez, José Damián López Sánchez, Teodorikez Wilfox Jiménez Rodríguez, José Luis Subiza Garrido-Lestache, Gabriela Canto Díez, Miguel Blanca Gómez, José Antonio Cornejo-García
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a59c81b97ae47a3a3447ed51b9a3921
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spelling	oai:doaj.org-article:2a59c81b97ae47a3a3447ed51b9a39212021-12-02T20:17:46ZSubjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.1932-620310.1371/journal.pone.0255305https://doaj.org/article/2a59c81b97ae47a3a3447ed51b9a39212021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255305https://doaj.org/toc/1932-6203Peach tree allergens are present in fruit, pollen, branches, and leaves, and can induce systemic, respiratory, cutaneous, and gastrointestinal symptoms. We studied the capacity of peach fruit/Pru p 1, Pru p 3, Pru p 4, Pru p 7 and peach pollen/Pru p 9 for inducing symptoms following oral or respiratory exposure in a large group of subjects. We included 716 adults (aged 21 to 83 y.o.) exposed to peach tree pollen and fruit intake in the study population. Participants completed a questionnaire and were skin tested with a panel of inhalant and food allergens, including peach tree pollen, Pru p 9 and peach fruit skin extract. Immunoglobulin E antibodies (SIgE) to Pru p 1, Pru p 3, Pru p 4 and Pru p 7 were quantified. Sensitised subjects underwent oral food challenge with peach fruit and nasal provocation test with peach tree pollen and Pru p 9. The prevalence of sensitisation to peach fruit was 5% and most of these had SIgE to Pru p 3, with a very low proportion to Pru p 4 SIgE and no SIgE to Pru p 1 and Pru p 7. In only 1.8%, anaphylaxis was the clinical entity induced. Cases with positive skin tests to peach and SIgE to Pru p 3 presented a good tolerance after oral challenge with peach fruit. The prevalence of skin sensitisation to peach tree pollen was 22%, with almost half recognising Pru p 9. This induced respiratory symptoms in those evaluated by nasal provocation. In a large population group exposed to peach fruit and peach tree pollen, most individuals were tolerant, even in those with SIgE to Pru p 3. A positive response to Pru p 9 was associated with respiratory allergy.Maria Luisa SomozaNatalia Pérez-SánchezLaura Victorio-PucheLaura Martín-PedrazaAngel Esteban RodríguezNatalia Blanca-LópezEva Abel Fernández GonzálezMaría Ruano-ZaragozaAna Prieto-Moreno PfeiferEnrique Fernández CaldasMiriam Morán MoralesFrancisco Javier Fernández SánchezJosé Damián López SánchezTeodorikez Wilfox Jiménez RodríguezJosé Luis Subiza Garrido-LestacheGabriela Canto DíezMiguel Blanca GómezJosé Antonio Cornejo-GarcíaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255305 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Luisa Somoza Natalia Pérez-Sánchez Laura Victorio-Puche Laura Martín-Pedraza Angel Esteban Rodríguez Natalia Blanca-López Eva Abel Fernández González María Ruano-Zaragoza Ana Prieto-Moreno Pfeifer Enrique Fernández Caldas Miriam Morán Morales Francisco Javier Fernández Sánchez José Damián López Sánchez Teodorikez Wilfox Jiménez Rodríguez José Luis Subiza Garrido-Lestache Gabriela Canto Díez Miguel Blanca Gómez José Antonio Cornejo-García Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.
description	Peach tree allergens are present in fruit, pollen, branches, and leaves, and can induce systemic, respiratory, cutaneous, and gastrointestinal symptoms. We studied the capacity of peach fruit/Pru p 1, Pru p 3, Pru p 4, Pru p 7 and peach pollen/Pru p 9 for inducing symptoms following oral or respiratory exposure in a large group of subjects. We included 716 adults (aged 21 to 83 y.o.) exposed to peach tree pollen and fruit intake in the study population. Participants completed a questionnaire and were skin tested with a panel of inhalant and food allergens, including peach tree pollen, Pru p 9 and peach fruit skin extract. Immunoglobulin E antibodies (SIgE) to Pru p 1, Pru p 3, Pru p 4 and Pru p 7 were quantified. Sensitised subjects underwent oral food challenge with peach fruit and nasal provocation test with peach tree pollen and Pru p 9. The prevalence of sensitisation to peach fruit was 5% and most of these had SIgE to Pru p 3, with a very low proportion to Pru p 4 SIgE and no SIgE to Pru p 1 and Pru p 7. In only 1.8%, anaphylaxis was the clinical entity induced. Cases with positive skin tests to peach and SIgE to Pru p 3 presented a good tolerance after oral challenge with peach fruit. The prevalence of skin sensitisation to peach tree pollen was 22%, with almost half recognising Pru p 9. This induced respiratory symptoms in those evaluated by nasal provocation. In a large population group exposed to peach fruit and peach tree pollen, most individuals were tolerant, even in those with SIgE to Pru p 3. A positive response to Pru p 9 was associated with respiratory allergy.
format	article
author	Maria Luisa Somoza Natalia Pérez-Sánchez Laura Victorio-Puche Laura Martín-Pedraza Angel Esteban Rodríguez Natalia Blanca-López Eva Abel Fernández González María Ruano-Zaragoza Ana Prieto-Moreno Pfeifer Enrique Fernández Caldas Miriam Morán Morales Francisco Javier Fernández Sánchez José Damián López Sánchez Teodorikez Wilfox Jiménez Rodríguez José Luis Subiza Garrido-Lestache Gabriela Canto Díez Miguel Blanca Gómez José Antonio Cornejo-García
author_facet	Maria Luisa Somoza Natalia Pérez-Sánchez Laura Victorio-Puche Laura Martín-Pedraza Angel Esteban Rodríguez Natalia Blanca-López Eva Abel Fernández González María Ruano-Zaragoza Ana Prieto-Moreno Pfeifer Enrique Fernández Caldas Miriam Morán Morales Francisco Javier Fernández Sánchez José Damián López Sánchez Teodorikez Wilfox Jiménez Rodríguez José Luis Subiza Garrido-Lestache Gabriela Canto Díez Miguel Blanca Gómez José Antonio Cornejo-García
author_sort	Maria Luisa Somoza
title	Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.
title_short	Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.
title_full	Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.
title_fullStr	Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.
title_full_unstemmed	Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.
title_sort	subjects develop tolerance to pru p 3 but respiratory allergy to pru p 9: a large study group from a peach exposed population.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2a59c81b97ae47a3a3447ed51b9a3921
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Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.

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