Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study

Introduction: Recent advances in nanotechnology have introduced new therapeutic materials for periodontal therapy. Previous studies showed that nanoparticles of silver provide high antibacterial activity. Taking this in consideration, it can be used in nonsurgical periodontal therapy. The present st...

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Autores principales: Pooja Kadam, Swapna Mahale, Prasad Sonar, Dipali Chaudhari, Shraddha Shimpi, Ankita Kathurwar
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Publicado: Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
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spelling oai:doaj.org-article:2a6307d674a54dd9a2c6f8279617efe92021-12-02T18:12:17ZEfficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study10.5281/zenodo.37496212695-5075https://doaj.org/article/2a6307d674a54dd9a2c6f8279617efe92020-04-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3749621https://doaj.org/toc/2695-5075Introduction: Recent advances in nanotechnology have introduced new therapeutic materials for periodontal therapy. Previous studies showed that nanoparticles of silver provide high antibacterial activity. Taking this in consideration, it can be used in nonsurgical periodontal therapy. The present study focuses on efficacy of subgingival local drug delivery of silver nanoparticles in comparison with tetracycline in chronic periodontitis. Methods: To understand the effect of silver nanoparticles and tetracycline gel in chronic periodontitis, patients which were divided in different: Group A: Scaling and root planning (SRP) with sub-gingival delivery of silver nanoparticles gel, Group B: SRP with sub-gingival delivery of tetracycline gel and Group C: SRP alone. The other data recorded was Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) at baseline (just before placement of gel), 1 month and 3 months of application of gel. Microbiological evaluation (Colony Forming Units, CFU) were recorded at baseline and after 3 months. Results: The results showed that the use of silver nanoparticles delivery after SRP was as efficacious as tetracycline subgingival delivery to treat chronic periodontitis patients. All the clinical as well as microbiological parameters showed statistically significant difference from baseline to 3 months in all the groups. Conclusions: As compared to other therapeutic modalities employed against infection, silver nanoparticles gel is non-toxic at given concentration, has no side effects and does not require complicated application method or any complex armamentarium. It is well tolerated and well accepted by the patients. Silver nanoparticles gel with SRP gives promising results and it can definitely aid in periodontal diseases.Pooja KadamSwapna MahalePrasad SonarDipali ChaudhariShraddha ShimpiAnkita KathurwarEmergency Department of Hospital San Pedro (Logroño, Spain)articlesilver nanoparticlesperiodontitischronic periodontitisMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 3, Pp 142-147 (2020)
institution DOAJ
collection DOAJ
language EN
topic silver nanoparticles
periodontitis
chronic periodontitis
Medicine (General)
R5-920
spellingShingle silver nanoparticles
periodontitis
chronic periodontitis
Medicine (General)
R5-920
Pooja Kadam
Swapna Mahale
Prasad Sonar
Dipali Chaudhari
Shraddha Shimpi
Ankita Kathurwar
Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study
description Introduction: Recent advances in nanotechnology have introduced new therapeutic materials for periodontal therapy. Previous studies showed that nanoparticles of silver provide high antibacterial activity. Taking this in consideration, it can be used in nonsurgical periodontal therapy. The present study focuses on efficacy of subgingival local drug delivery of silver nanoparticles in comparison with tetracycline in chronic periodontitis. Methods: To understand the effect of silver nanoparticles and tetracycline gel in chronic periodontitis, patients which were divided in different: Group A: Scaling and root planning (SRP) with sub-gingival delivery of silver nanoparticles gel, Group B: SRP with sub-gingival delivery of tetracycline gel and Group C: SRP alone. The other data recorded was Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) at baseline (just before placement of gel), 1 month and 3 months of application of gel. Microbiological evaluation (Colony Forming Units, CFU) were recorded at baseline and after 3 months. Results: The results showed that the use of silver nanoparticles delivery after SRP was as efficacious as tetracycline subgingival delivery to treat chronic periodontitis patients. All the clinical as well as microbiological parameters showed statistically significant difference from baseline to 3 months in all the groups. Conclusions: As compared to other therapeutic modalities employed against infection, silver nanoparticles gel is non-toxic at given concentration, has no side effects and does not require complicated application method or any complex armamentarium. It is well tolerated and well accepted by the patients. Silver nanoparticles gel with SRP gives promising results and it can definitely aid in periodontal diseases.
format article
author Pooja Kadam
Swapna Mahale
Prasad Sonar
Dipali Chaudhari
Shraddha Shimpi
Ankita Kathurwar
author_facet Pooja Kadam
Swapna Mahale
Prasad Sonar
Dipali Chaudhari
Shraddha Shimpi
Ankita Kathurwar
author_sort Pooja Kadam
title Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study
title_short Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study
title_full Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study
title_fullStr Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study
title_full_unstemmed Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study
title_sort efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study
publisher Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate 2020
url https://doaj.org/article/2a6307d674a54dd9a2c6f8279617efe9
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