Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

An increasing number of amyloid structures are determined. Here, the authors present the structure-based amyloid core sequence prediction method Cordax that is based on machine learning and allows the detection of aggregation-prone regions with higher solubility, disorder and surface exposure, and f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nikolaos Louros, Gabriele Orlando, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a64a32adfa14ef9a2a2d237d6f0b10b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2a64a32adfa14ef9a2a2d237d6f0b10b
record_format	dspace
spelling	oai:doaj.org-article:2a64a32adfa14ef9a2a2d237d6f0b10b2021-12-02T16:31:47ZStructure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities10.1038/s41467-020-17207-32041-1723https://doaj.org/article/2a64a32adfa14ef9a2a2d237d6f0b10b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17207-3https://doaj.org/toc/2041-1723An increasing number of amyloid structures are determined. Here, the authors present the structure-based amyloid core sequence prediction method Cordax that is based on machine learning and allows the detection of aggregation-prone regions with higher solubility, disorder and surface exposure, and furthermore predicts the structural topology, orientation and overall architecture of the resulting putative fibril core.Nikolaos LourosGabriele OrlandoMatthias De VleeschouwerFrederic RousseauJoost SchymkowitzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolaos Louros Gabriele Orlando Matthias De Vleeschouwer Frederic Rousseau Joost Schymkowitz Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
description	An increasing number of amyloid structures are determined. Here, the authors present the structure-based amyloid core sequence prediction method Cordax that is based on machine learning and allows the detection of aggregation-prone regions with higher solubility, disorder and surface exposure, and furthermore predicts the structural topology, orientation and overall architecture of the resulting putative fibril core.
format	article
author	Nikolaos Louros Gabriele Orlando Matthias De Vleeschouwer Frederic Rousseau Joost Schymkowitz
author_facet	Nikolaos Louros Gabriele Orlando Matthias De Vleeschouwer Frederic Rousseau Joost Schymkowitz
author_sort	Nikolaos Louros
title	Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_short	Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_full	Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_fullStr	Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_full_unstemmed	Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_sort	structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2a64a32adfa14ef9a2a2d237d6f0b10b
work_keys_str_mv	AT nikolaoslouros structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities AT gabrieleorlando structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities AT matthiasdevleeschouwer structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities AT fredericrousseau structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities AT joostschymkowitz structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities
_version_	1718383860116357120

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

Ejemplares similares