Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data

DNA modification generates unique electric signals in Oxford Nanopore sequencing data but the signals can be complicated to decipher. Here, the authors develop a deep learning framework, DeepMod, to detect DNA base modifications including 5mC and 6mA using Nanopore sequencing data

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Autores principales:	Qian Liu, Li Fang, Guoliang Yu, Depeng Wang, Chuan-Le Xiao, Kai Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a64c8015b9e434c94ff1733e2720d34
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spelling	oai:doaj.org-article:2a64c8015b9e434c94ff1733e2720d342021-12-02T17:02:19ZDetection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data10.1038/s41467-019-10168-22041-1723https://doaj.org/article/2a64c8015b9e434c94ff1733e2720d342019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10168-2https://doaj.org/toc/2041-1723DNA modification generates unique electric signals in Oxford Nanopore sequencing data but the signals can be complicated to decipher. Here, the authors develop a deep learning framework, DeepMod, to detect DNA base modifications including 5mC and 6mA using Nanopore sequencing dataQian LiuLi FangGuoliang YuDepeng WangChuan-Le XiaoKai WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Liu Li Fang Guoliang Yu Depeng Wang Chuan-Le Xiao Kai Wang Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
description	DNA modification generates unique electric signals in Oxford Nanopore sequencing data but the signals can be complicated to decipher. Here, the authors develop a deep learning framework, DeepMod, to detect DNA base modifications including 5mC and 6mA using Nanopore sequencing data
format	article
author	Qian Liu Li Fang Guoliang Yu Depeng Wang Chuan-Le Xiao Kai Wang
author_facet	Qian Liu Li Fang Guoliang Yu Depeng Wang Chuan-Le Xiao Kai Wang
author_sort	Qian Liu
title	Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
title_short	Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
title_full	Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
title_fullStr	Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
title_full_unstemmed	Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
title_sort	detection of dna base modifications by deep recurrent neural network on oxford nanopore sequencing data
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2a64c8015b9e434c94ff1733e2720d34
work_keys_str_mv	AT qianliu detectionofdnabasemodificationsbydeeprecurrentneuralnetworkonoxfordnanoporesequencingdata AT lifang detectionofdnabasemodificationsbydeeprecurrentneuralnetworkonoxfordnanoporesequencingdata AT guoliangyu detectionofdnabasemodificationsbydeeprecurrentneuralnetworkonoxfordnanoporesequencingdata AT depengwang detectionofdnabasemodificationsbydeeprecurrentneuralnetworkonoxfordnanoporesequencingdata AT chuanlexiao detectionofdnabasemodificationsbydeeprecurrentneuralnetworkonoxfordnanoporesequencingdata AT kaiwang detectionofdnabasemodificationsbydeeprecurrentneuralnetworkonoxfordnanoporesequencingdata
_version_	1718381897427451904

Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data

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