Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?

To study and critically analyze the published evidence on correlation of hormonal abnormalities and endothelial dysfunction (ED) in polycystic ovary syndrome (PCOS) through a systematic review. The databases including MEDLINE, PubMed, Up-To-Date, and Science Direct were searched using Medical subjec...

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Autor principal:	Rajani Dube
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2016
Materias:	adipocyte-secreted hormones endothelial dysfunction estrogen follicular stimulating hormone hyperandrogenism insulin resistance luteinizing hormone polycystic ovary syndrome prolactin Medicine R
Acceso en línea:	https://doaj.org/article/2a670222bba146b9bc7a98d640f1e194
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spelling	oai:doaj.org-article:2a670222bba146b9bc7a98d640f1e1942021-12-02T16:37:41ZDoes endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?2231-07702249-446410.4103/2231-0770.191445https://doaj.org/article/2a670222bba146b9bc7a98d640f1e1942016-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.191445https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464To study and critically analyze the published evidence on correlation of hormonal abnormalities and endothelial dysfunction (ED) in polycystic ovary syndrome (PCOS) through a systematic review. The databases including MEDLINE, PubMed, Up-To-Date, and Science Direct were searched using Medical subject handling terms and free text term keywords such as endocrine abnormalities in PCOS, ED assessment in PCOS, ED in combination with insulin resistance (IR), hyperandrogenism (HA), increased free testosterone, free androgen index (FAI), gonadotrophin levels, luteinizing hormone (LH), prolactin, estrogen, adipocytokines to search trials, and observational studies published from January 1987 to September 2015. Authors of original studies were contacted for additional data when necessary. PCOS increases the risk of cardiovascular disease in women. ED, which is a reliable indicator of cardiovascular risk in general population, is seen in most (but not all) women with PCOS. IR, seen in 70% patients with PCOS, is associated with ED in these women, but patients can have normal endothelial function even in the presence of IR. Free testosterone and FAI are consistently associated with ED, but endothelial function can be normal despite HA. Estradiol (not estrone) appears to be protective against ED though estrone is the predominant estrogen produced in PCOS. Increased levels of adipocytokines (visfatin) are promising in predicting ED and cardiovascular risk. However, more studies are required focusing on direct correlation of levels of prolactin, LH, estrone, and visfatin with ED in PCOS.Rajani DubeThieme Medical and Scientific Publishers Pvt. Ltd.articleadipocyte-secreted hormonesendothelial dysfunctionestrogenfollicular stimulating hormonehyperandrogenisminsulin resistanceluteinizing hormonepolycystic ovary syndromeprolactinMedicineRENAvicenna Journal of Medicine, Vol 06, Iss 04, Pp 91-102 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipocyte-secreted hormones endothelial dysfunction estrogen follicular stimulating hormone hyperandrogenism insulin resistance luteinizing hormone polycystic ovary syndrome prolactin Medicine R
spellingShingle	adipocyte-secreted hormones endothelial dysfunction estrogen follicular stimulating hormone hyperandrogenism insulin resistance luteinizing hormone polycystic ovary syndrome prolactin Medicine R Rajani Dube Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?
description	To study and critically analyze the published evidence on correlation of hormonal abnormalities and endothelial dysfunction (ED) in polycystic ovary syndrome (PCOS) through a systematic review. The databases including MEDLINE, PubMed, Up-To-Date, and Science Direct were searched using Medical subject handling terms and free text term keywords such as endocrine abnormalities in PCOS, ED assessment in PCOS, ED in combination with insulin resistance (IR), hyperandrogenism (HA), increased free testosterone, free androgen index (FAI), gonadotrophin levels, luteinizing hormone (LH), prolactin, estrogen, adipocytokines to search trials, and observational studies published from January 1987 to September 2015. Authors of original studies were contacted for additional data when necessary. PCOS increases the risk of cardiovascular disease in women. ED, which is a reliable indicator of cardiovascular risk in general population, is seen in most (but not all) women with PCOS. IR, seen in 70% patients with PCOS, is associated with ED in these women, but patients can have normal endothelial function even in the presence of IR. Free testosterone and FAI are consistently associated with ED, but endothelial function can be normal despite HA. Estradiol (not estrone) appears to be protective against ED though estrone is the predominant estrogen produced in PCOS. Increased levels of adipocytokines (visfatin) are promising in predicting ED and cardiovascular risk. However, more studies are required focusing on direct correlation of levels of prolactin, LH, estrone, and visfatin with ED in PCOS.
format	article
author	Rajani Dube
author_facet	Rajani Dube
author_sort	Rajani Dube
title	Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?
title_short	Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?
title_full	Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?
title_fullStr	Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?
title_full_unstemmed	Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?
title_sort	does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2016
url	https://doaj.org/article/2a670222bba146b9bc7a98d640f1e194
work_keys_str_mv	AT rajanidube doesendothelialdysfunctioncorrelatewithendocrinalabnormalitiesinpatientswithpolycysticovarysyndrome
_version_	1718383620981260288

Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome?

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