PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE

Abstract. The aim of study was to investigate peculiarities of specific immune responses in vaccinated and unvaccinated measles convalescents. Twelve infants with natural measles infection at 5–7th day after onset of rash (Group 1), 14 adults with natural measles infection at 5–7th day (Group 2), 13...

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Autores principales:	A. P. Toptygina, T. A. Mamaeva, V. A. Alioshkin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	measles specific humoral immune response igg subclasses. Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/2a68397294a34f62b7238cbce95b7cf0
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spelling	oai:doaj.org-article:2a68397294a34f62b7238cbce95b7cf02021-11-22T07:09:46ZPECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE2220-76192313-739810.15789/2220-7619-2013-3-243-250https://doaj.org/article/2a68397294a34f62b7238cbce95b7cf02014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/136https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The aim of study was to investigate peculiarities of specific immune responses in vaccinated and unvaccinated measles convalescents. Twelve infants with natural measles infection at 5–7th day after onset of rash (Group 1), 14 adults with natural measles infection at 5–7th day (Group 2), 13 adults with measles at 12–15th day after onset of rash (Group 3), and 15 measles patients previously vaccinated against measles (Group 4) were examined. Fifteen healthy adults had twodose measles vaccination at 1 year and 6 years old (Group 5), and 17 healthy adults had measles many years ago (Group 6) were included in the study as a control groups. Specific IgM, IgA, IgG antibodies in serum, and their subclasses and avidity were tested by ELISA. High level of specific IgM and IgA-antibodies, and increasing of low-avidity IgG-antibodies, predominantly IgG3 subclass were typical for the humoral immune response in unvaccinated patients. On the contrary, lower level of IgM and the highest level of specific IgA and high-avidity IgG, predominantly IgG1 subclass characterized the group of previously vaccinated measles patients. The humoral immune response in vaccinated volunteers was characterized by lower level of specific IgA, IgG and avidity than in adults had measles in their childhood (group 6). The laboratory plays a critical role in case classification when rash and fever develop in persons who have possibly been exposed to measles. Waning of measles antibody, however, does not necessarily equate to waning immunity, because B-memory cells responses can increase of the antibody synthesis.A. P. ToptyginaT. A. MamaevaV. A. AlioshkinSankt-Peterburg : NIIÈM imeni Pasteraarticlemeaslesspecific humoral immune responseigg subclasses.Infectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 3, Iss 3, Pp 243-250 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles specific humoral immune response igg subclasses. Infectious and parasitic diseases RC109-216
spellingShingle	measles specific humoral immune response igg subclasses. Infectious and parasitic diseases RC109-216 A. P. Toptygina T. A. Mamaeva V. A. Alioshkin PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE
description	Abstract. The aim of study was to investigate peculiarities of specific immune responses in vaccinated and unvaccinated measles convalescents. Twelve infants with natural measles infection at 5–7th day after onset of rash (Group 1), 14 adults with natural measles infection at 5–7th day (Group 2), 13 adults with measles at 12–15th day after onset of rash (Group 3), and 15 measles patients previously vaccinated against measles (Group 4) were examined. Fifteen healthy adults had twodose measles vaccination at 1 year and 6 years old (Group 5), and 17 healthy adults had measles many years ago (Group 6) were included in the study as a control groups. Specific IgM, IgA, IgG antibodies in serum, and their subclasses and avidity were tested by ELISA. High level of specific IgM and IgA-antibodies, and increasing of low-avidity IgG-antibodies, predominantly IgG3 subclass were typical for the humoral immune response in unvaccinated patients. On the contrary, lower level of IgM and the highest level of specific IgA and high-avidity IgG, predominantly IgG1 subclass characterized the group of previously vaccinated measles patients. The humoral immune response in vaccinated volunteers was characterized by lower level of specific IgA, IgG and avidity than in adults had measles in their childhood (group 6). The laboratory plays a critical role in case classification when rash and fever develop in persons who have possibly been exposed to measles. Waning of measles antibody, however, does not necessarily equate to waning immunity, because B-memory cells responses can increase of the antibody synthesis.
format	article
author	A. P. Toptygina T. A. Mamaeva V. A. Alioshkin
author_facet	A. P. Toptygina T. A. Mamaeva V. A. Alioshkin
author_sort	A. P. Toptygina
title	PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE
title_short	PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE
title_full	PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE
title_fullStr	PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE
title_full_unstemmed	PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE
title_sort	peculiarities of specific humoral mesles immune response
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/2a68397294a34f62b7238cbce95b7cf0
work_keys_str_mv	AT aptoptygina peculiaritiesofspecifichumoralmeslesimmuneresponse AT tamamaeva peculiaritiesofspecifichumoralmeslesimmuneresponse AT vaalioshkin peculiaritiesofspecifichumoralmeslesimmuneresponse
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PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE

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