Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

Polyploidy is a common feature in normal hepatocytes, however, the pathophysiological function of hepatic hyperpolyploidy is unclear. Here, the authors show that genotoxic stress induces accumulation of hyperpolyploid hepatocytes around the centrilobular region of the liver, which may indicate the o...

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Autores principales:	Heng Lin, Yen-Sung Huang, Jean-Michel Fustin, Masao Doi, Huatao Chen, Hui-Huang Lai, Shu-Hui Lin, Yen-Lurk Lee, Pei-Chih King, Hsien-San Hou, Hao-Wen Chen, Pei-Yun Young, Hsu-Wen Chao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce
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spelling	oai:doaj.org-article:2a6b0a8610cd4b32b27ac9dde0bc48ce2021-12-02T14:16:40ZHyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver10.1038/s41467-020-20572-82041-1723https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20572-8https://doaj.org/toc/2041-1723Polyploidy is a common feature in normal hepatocytes, however, the pathophysiological function of hepatic hyperpolyploidy is unclear. Here, the authors show that genotoxic stress induces accumulation of hyperpolyploid hepatocytes around the centrilobular region of the liver, which may indicate the origin of preneoplastic formation.Heng LinYen-Sung HuangJean-Michel FustinMasao DoiHuatao ChenHui-Huang LaiShu-Hui LinYen-Lurk LeePei-Chih KingHsien-San HouHao-Wen ChenPei-Yun YoungHsu-Wen ChaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heng Lin Yen-Sung Huang Jean-Michel Fustin Masao Doi Huatao Chen Hui-Huang Lai Shu-Hui Lin Yen-Lurk Lee Pei-Chih King Hsien-San Hou Hao-Wen Chen Pei-Yun Young Hsu-Wen Chao Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
description	Polyploidy is a common feature in normal hepatocytes, however, the pathophysiological function of hepatic hyperpolyploidy is unclear. Here, the authors show that genotoxic stress induces accumulation of hyperpolyploid hepatocytes around the centrilobular region of the liver, which may indicate the origin of preneoplastic formation.
format	article
author	Heng Lin Yen-Sung Huang Jean-Michel Fustin Masao Doi Huatao Chen Hui-Huang Lai Shu-Hui Lin Yen-Lurk Lee Pei-Chih King Hsien-San Hou Hao-Wen Chen Pei-Yun Young Hsu-Wen Chao
author_facet	Heng Lin Yen-Sung Huang Jean-Michel Fustin Masao Doi Huatao Chen Hui-Huang Lai Shu-Hui Lin Yen-Lurk Lee Pei-Chih King Hsien-San Hou Hao-Wen Chen Pei-Yun Young Hsu-Wen Chao
author_sort	Heng Lin
title	Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
title_short	Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
title_full	Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
title_fullStr	Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
title_full_unstemmed	Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
title_sort	hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce
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Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

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