Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.

The pedunculopontine area (PPNa) including the pedunculopontine and cuneiform nuclei, belongs to the mesencephalic locomotor region. Little is known about the oscillatory mechanisms underlying the function of this region in postural and gait control. We examined the modulations of the oscillatory ac...

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Autores principales:	Valerie Fraix, Julien Bastin, Olivier David, Laurent Goetz, Murielle Ferraye, Alim-Louis Benabid, Stephan Chabardes, Pierre Pollak, Bettina Debû
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a6b25de9d26440195e11e3ec7f0abe8
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spelling	oai:doaj.org-article:2a6b25de9d26440195e11e3ec7f0abe82021-11-18T08:39:52ZPedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.1932-620310.1371/journal.pone.0083919https://doaj.org/article/2a6b25de9d26440195e11e3ec7f0abe82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386308/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The pedunculopontine area (PPNa) including the pedunculopontine and cuneiform nuclei, belongs to the mesencephalic locomotor region. Little is known about the oscillatory mechanisms underlying the function of this region in postural and gait control. We examined the modulations of the oscillatory activity of the PPNa and cortex during stepping, a surrogate of gait, and stance in seven Parkinson's disease patients who received bilateral PPNa implantation for disabling freezing of gait (FOG). In the days following the surgery, we recorded behavioural data together with the local field potentials of the PPNa during sitting, standing and stepping-in-place, under two dopaminergic medication conditions (OFF and ON levodopa). Our results showed that OFF levodopa, all subjects had FOG during step-in-place trials, while ON levodopa, stepping was effective (mean duration of FOG decreasing from 61.7±36.1% to 7.3±10.1% of trial duration). ON levodopa, there was an increase in PPNa alpha (5-12 Hz) oscillatory activity and a decrease in beta (13-35 Hz) and gamma (65-90 Hz) bands activity. PPNa activity was not modulated during quiet standing and sitting. Our results confirm the role of the PPNa in the regulation of gait and suggest that, in Parkinson disease, gait difficulties could be related to an imbalance between low and higher frequencies.Valerie FraixJulien BastinOlivier DavidLaurent GoetzMurielle FerrayeAlim-Louis BenabidStephan ChabardesPierre PollakBettina DebûPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83919 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valerie Fraix Julien Bastin Olivier David Laurent Goetz Murielle Ferraye Alim-Louis Benabid Stephan Chabardes Pierre Pollak Bettina Debû Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
description	The pedunculopontine area (PPNa) including the pedunculopontine and cuneiform nuclei, belongs to the mesencephalic locomotor region. Little is known about the oscillatory mechanisms underlying the function of this region in postural and gait control. We examined the modulations of the oscillatory activity of the PPNa and cortex during stepping, a surrogate of gait, and stance in seven Parkinson's disease patients who received bilateral PPNa implantation for disabling freezing of gait (FOG). In the days following the surgery, we recorded behavioural data together with the local field potentials of the PPNa during sitting, standing and stepping-in-place, under two dopaminergic medication conditions (OFF and ON levodopa). Our results showed that OFF levodopa, all subjects had FOG during step-in-place trials, while ON levodopa, stepping was effective (mean duration of FOG decreasing from 61.7±36.1% to 7.3±10.1% of trial duration). ON levodopa, there was an increase in PPNa alpha (5-12 Hz) oscillatory activity and a decrease in beta (13-35 Hz) and gamma (65-90 Hz) bands activity. PPNa activity was not modulated during quiet standing and sitting. Our results confirm the role of the PPNa in the regulation of gait and suggest that, in Parkinson disease, gait difficulties could be related to an imbalance between low and higher frequencies.
format	article
author	Valerie Fraix Julien Bastin Olivier David Laurent Goetz Murielle Ferraye Alim-Louis Benabid Stephan Chabardes Pierre Pollak Bettina Debû
author_facet	Valerie Fraix Julien Bastin Olivier David Laurent Goetz Murielle Ferraye Alim-Louis Benabid Stephan Chabardes Pierre Pollak Bettina Debû
author_sort	Valerie Fraix
title	Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
title_short	Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
title_full	Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
title_fullStr	Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
title_full_unstemmed	Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
title_sort	pedunculopontine nucleus area oscillations during stance, stepping and freezing in parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2a6b25de9d26440195e11e3ec7f0abe8
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Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.

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