Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors

The objectives of this study were to evaluate urinary beta-2-microglobulin (β2M) levels in long-term childhood cancer survivors and to establish its association with anticancer drug-induced nephrotoxicity. The study consisted of 165 childhood cancer survivors (CCS) who were in continuous complete re...

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Autores principales:	Eryk Latoch, Katarzyna Konończuk, Katarzyna Taranta-Janusz, Katarzyna Muszyńska-Rosłan, Magdalena Sawicka, Anna Wasilewska, Maryna Krawczuk-Rybak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	B2M cancer CCS children CKD chronic kidney disease Medicine R
Acceso en línea:	https://doaj.org/article/2a6c99a70b3648c59092fdea83338363
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spelling	oai:doaj.org-article:2a6c99a70b3648c59092fdea833383632021-11-25T18:01:16ZUrinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors10.3390/jcm102252792077-0383https://doaj.org/article/2a6c99a70b3648c59092fdea833383632021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5279https://doaj.org/toc/2077-0383The objectives of this study were to evaluate urinary beta-2-microglobulin (β2M) levels in long-term childhood cancer survivors and to establish its association with anticancer drug-induced nephrotoxicity. The study consisted of 165 childhood cancer survivors (CCS) who were in continuous complete remission. We reported that CCS had a significantly higher level of β2M (<i>p</i> < 0.001) and β2M/Cr. ratio (<i>p</i> < 0.05) than healthy peers. Among all participants, 24 (14.5%) had decreased eGFR (<90 mL/min/1.73 m<sup>2</sup>). A significant positive correlation between β2M/Cr. ratio and body mass index (coef. 14.48, <i>p</i> = 0.046) was found. Furthermore, higher levels of urinary β2M were detected among CCS with a longer follow-up time (over 5 years) after treatment. Subjects with decreased eGFR showed statistically higher urinary β2M levels (20.06 ± 21.56 ng/mL vs. 8.55 ± 3.65 ng/mL, <i>p</i> = 0.007) compared with the healthy peers. Twelve survivors (7.2%) presented hyperfiltration and they had higher urinary β2M levels than CCS with normal glomerular filtration (46.33 ± 93.11 vs. 8.55 ± 3.65 ng/mL, <i>p</i> = 0.029). This study did not reveal an association between potential treatment-related risk factors such as chemotherapy, surgery, radiotherapy, and the urinary β2M level. The relationship between treatment with abdominal radiotherapy and reduced eGFR was confirmed (<i>p</i> < 0.05). We demonstrated that urinary beta-2-microglobulin may play a role in the subtle kidney injury in childhood cancer survivors; however, the treatment-related factors affecting the β2M level remain unknown. Further prospective studies with a longer follow-up time are needed to confirm the utility of urinary β2M and its role as a non-invasive biomarker of renal dysfunction.Eryk LatochKatarzyna KonończukKatarzyna Taranta-JanuszKatarzyna Muszyńska-RosłanMagdalena SawickaAnna WasilewskaMaryna Krawczuk-RybakMDPI AGarticleB2McancerCCSchildrenCKDchronic kidney diseaseMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5279, p 5279 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	B2M cancer CCS children CKD chronic kidney disease Medicine R
spellingShingle	B2M cancer CCS children CKD chronic kidney disease Medicine R Eryk Latoch Katarzyna Konończuk Katarzyna Taranta-Janusz Katarzyna Muszyńska-Rosłan Magdalena Sawicka Anna Wasilewska Maryna Krawczuk-Rybak Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors
description	The objectives of this study were to evaluate urinary beta-2-microglobulin (β2M) levels in long-term childhood cancer survivors and to establish its association with anticancer drug-induced nephrotoxicity. The study consisted of 165 childhood cancer survivors (CCS) who were in continuous complete remission. We reported that CCS had a significantly higher level of β2M (<i>p</i> < 0.001) and β2M/Cr. ratio (<i>p</i> < 0.05) than healthy peers. Among all participants, 24 (14.5%) had decreased eGFR (<90 mL/min/1.73 m<sup>2</sup>). A significant positive correlation between β2M/Cr. ratio and body mass index (coef. 14.48, <i>p</i> = 0.046) was found. Furthermore, higher levels of urinary β2M were detected among CCS with a longer follow-up time (over 5 years) after treatment. Subjects with decreased eGFR showed statistically higher urinary β2M levels (20.06 ± 21.56 ng/mL vs. 8.55 ± 3.65 ng/mL, <i>p</i> = 0.007) compared with the healthy peers. Twelve survivors (7.2%) presented hyperfiltration and they had higher urinary β2M levels than CCS with normal glomerular filtration (46.33 ± 93.11 vs. 8.55 ± 3.65 ng/mL, <i>p</i> = 0.029). This study did not reveal an association between potential treatment-related risk factors such as chemotherapy, surgery, radiotherapy, and the urinary β2M level. The relationship between treatment with abdominal radiotherapy and reduced eGFR was confirmed (<i>p</i> < 0.05). We demonstrated that urinary beta-2-microglobulin may play a role in the subtle kidney injury in childhood cancer survivors; however, the treatment-related factors affecting the β2M level remain unknown. Further prospective studies with a longer follow-up time are needed to confirm the utility of urinary β2M and its role as a non-invasive biomarker of renal dysfunction.
format	article
author	Eryk Latoch Katarzyna Konończuk Katarzyna Taranta-Janusz Katarzyna Muszyńska-Rosłan Magdalena Sawicka Anna Wasilewska Maryna Krawczuk-Rybak
author_facet	Eryk Latoch Katarzyna Konończuk Katarzyna Taranta-Janusz Katarzyna Muszyńska-Rosłan Magdalena Sawicka Anna Wasilewska Maryna Krawczuk-Rybak
author_sort	Eryk Latoch
title	Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors
title_short	Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors
title_full	Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors
title_fullStr	Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors
title_full_unstemmed	Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors
title_sort	urinary beta-2-microglobulin and late nephrotoxicity in childhood cancer survivors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2a6c99a70b3648c59092fdea83338363
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Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors

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