Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets

AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved in mediating growth and development. However,...

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Autores principales:	Yinqi Zhang, Chengqi Gao, Fei Cao, Ying Wu, Shuanggang Chen, Xue Han, Jingqin Mo, Zhiyu Qiu, Weijun Fan, Penghui Zhou, Lujun Shen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pan-cancer IGF-1 IGF-1R prognostic biomarker immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2a6cd8c3041a4ec3bee67aec9a9a5eea
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spelling	oai:doaj.org-article:2a6cd8c3041a4ec3bee67aec9a9a5eea2021-11-05T12:11:27ZPan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets2234-943X10.3389/fonc.2021.755341https://doaj.org/article/2a6cd8c3041a4ec3bee67aec9a9a5eea2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.755341/fullhttps://doaj.org/toc/2234-943XAimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved in mediating growth and development. However, the correlations of IGF-1 and IGF-1R to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear.MethodThis research comprehensively analyzed the expression pattern of IGF-1 and IGF-1R and the influence of IGF-1 and IGF-1R on clinical significance in prognosis prediction among 33 types of malignancies using The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE) databases. The correlation between IGF-1, IGF-1R, and cancer immunity was explored.ResultsIGF-1 and IGF-1R displayed inconsistent gene expression levels among diverse cancer cell lines. Typically, high expression level of IGF-1 and IGF-1R was detected in most malignant tumors. High expression of IGF-1 was closely bound up with the unfavorable overall survival (OS) for patients in BLCA, CHOL, and LAML upon Cox and Kaplan-Meier analyses. While high expression of IGF-1R was closely bound up with the unfavorable overall survival (OS) for patients in BLCA, LIHC, and LUAD. Furthermore, high expression level of IGF-1 and IGF-1R were closely connected with high degrees of tumor infiltrates, including CD4+ T cell, dendritic cells, and macrophages. In addition, we found that IGF-1 was commonly positively correlated with the expression of gene markers including LAIR1, ICOS, CD40LG, CTLA4, CD48, CD28, CD200R1, HAVCR2, and CD86. Whereas, IGF-1R was commonly positively correlated with the expression of gene markers including NRP1 and CD276. More importantly, IGF-1 and IGF-1R expression were correlated with tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), and DNA methyltransferase (DNMT) of different types of cancers.ConclusionsThe impact of high IGF-1 and IGF-1R on prognosis and immune infiltrates differs across cancer types. Anti-IGF-1R therapy may inhibit tumor growth and contribute to immunotherapy in LIHC and KIRC.Yinqi ZhangYinqi ZhangChengqi GaoFei CaoFei CaoYing WuYing WuShuanggang ChenXue HanXue HanJingqin MoZhiyu QiuZhiyu QiuWeijun FanWeijun FanPenghui ZhouLujun ShenLujun ShenFrontiers Media S.A.articlepan-cancerIGF-1IGF-1Rprognostic biomarkerimmunityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pan-cancer IGF-1 IGF-1R prognostic biomarker immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pan-cancer IGF-1 IGF-1R prognostic biomarker immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yinqi Zhang Yinqi Zhang Chengqi Gao Fei Cao Fei Cao Ying Wu Ying Wu Shuanggang Chen Xue Han Xue Han Jingqin Mo Zhiyu Qiu Zhiyu Qiu Weijun Fan Weijun Fan Penghui Zhou Lujun Shen Lujun Shen Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
description	AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved in mediating growth and development. However, the correlations of IGF-1 and IGF-1R to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear.MethodThis research comprehensively analyzed the expression pattern of IGF-1 and IGF-1R and the influence of IGF-1 and IGF-1R on clinical significance in prognosis prediction among 33 types of malignancies using The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE) databases. The correlation between IGF-1, IGF-1R, and cancer immunity was explored.ResultsIGF-1 and IGF-1R displayed inconsistent gene expression levels among diverse cancer cell lines. Typically, high expression level of IGF-1 and IGF-1R was detected in most malignant tumors. High expression of IGF-1 was closely bound up with the unfavorable overall survival (OS) for patients in BLCA, CHOL, and LAML upon Cox and Kaplan-Meier analyses. While high expression of IGF-1R was closely bound up with the unfavorable overall survival (OS) for patients in BLCA, LIHC, and LUAD. Furthermore, high expression level of IGF-1 and IGF-1R were closely connected with high degrees of tumor infiltrates, including CD4+ T cell, dendritic cells, and macrophages. In addition, we found that IGF-1 was commonly positively correlated with the expression of gene markers including LAIR1, ICOS, CD40LG, CTLA4, CD48, CD28, CD200R1, HAVCR2, and CD86. Whereas, IGF-1R was commonly positively correlated with the expression of gene markers including NRP1 and CD276. More importantly, IGF-1 and IGF-1R expression were correlated with tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), and DNA methyltransferase (DNMT) of different types of cancers.ConclusionsThe impact of high IGF-1 and IGF-1R on prognosis and immune infiltrates differs across cancer types. Anti-IGF-1R therapy may inhibit tumor growth and contribute to immunotherapy in LIHC and KIRC.
format	article
author	Yinqi Zhang Yinqi Zhang Chengqi Gao Fei Cao Fei Cao Ying Wu Ying Wu Shuanggang Chen Xue Han Xue Han Jingqin Mo Zhiyu Qiu Zhiyu Qiu Weijun Fan Weijun Fan Penghui Zhou Lujun Shen Lujun Shen
author_facet	Yinqi Zhang Yinqi Zhang Chengqi Gao Fei Cao Fei Cao Ying Wu Ying Wu Shuanggang Chen Xue Han Xue Han Jingqin Mo Zhiyu Qiu Zhiyu Qiu Weijun Fan Weijun Fan Penghui Zhou Lujun Shen Lujun Shen
author_sort	Yinqi Zhang
title	Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
title_short	Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
title_full	Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
title_fullStr	Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
title_full_unstemmed	Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
title_sort	pan-cancer analysis of igf-1 and igf-1r as potential prognostic biomarkers and immunotherapy targets
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2a6cd8c3041a4ec3bee67aec9a9a5eea
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Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets

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