Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma

Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To inves...

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Autores principales: Javier Fernández-Mateos, Raquel Seijas-Tamayo, Juan Carlos Adansa Klain, Miguel Pastor Borgoñón, Elisabeth Pérez-Ruiz, Ricard Mesía, Elvira del Barco, Carmen Salvador Coloma, Antonio Rueda Dominguez, Javier Caballero Daroqui, Encarnación Fernández Ruiz, Juan Jesús Cruz-Hernández, Rogelio González-Sarmiento
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2a6d4d6151124d12a8c1eba89b44d361
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spelling oai:doaj.org-article:2a6d4d6151124d12a8c1eba89b44d3612021-12-02T16:06:48ZAnalysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma10.1038/s41598-017-07270-02045-2322https://doaj.org/article/2a6d4d6151124d12a8c1eba89b44d3612017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07270-0https://doaj.org/toc/2045-2322Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma. ATG5 rs2245214 SNP was not associated with any location. Overall, our results indicate the importance of the autophagy pathway in the susceptibility of head and neck squamous cell carcinoma and demonstrate the heterogeneity between its locations encompassed under a single terminology.Javier Fernández-MateosRaquel Seijas-TamayoJuan Carlos Adansa KlainMiguel Pastor BorgoñónElisabeth Pérez-RuizRicard MesíaElvira del BarcoCarmen Salvador ColomaAntonio Rueda DominguezJavier Caballero DaroquiEncarnación Fernández RuizJuan Jesús Cruz-HernándezRogelio González-SarmientoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Javier Fernández-Mateos
Raquel Seijas-Tamayo
Juan Carlos Adansa Klain
Miguel Pastor Borgoñón
Elisabeth Pérez-Ruiz
Ricard Mesía
Elvira del Barco
Carmen Salvador Coloma
Antonio Rueda Dominguez
Javier Caballero Daroqui
Encarnación Fernández Ruiz
Juan Jesús Cruz-Hernández
Rogelio González-Sarmiento
Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
description Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma. ATG5 rs2245214 SNP was not associated with any location. Overall, our results indicate the importance of the autophagy pathway in the susceptibility of head and neck squamous cell carcinoma and demonstrate the heterogeneity between its locations encompassed under a single terminology.
format article
author Javier Fernández-Mateos
Raquel Seijas-Tamayo
Juan Carlos Adansa Klain
Miguel Pastor Borgoñón
Elisabeth Pérez-Ruiz
Ricard Mesía
Elvira del Barco
Carmen Salvador Coloma
Antonio Rueda Dominguez
Javier Caballero Daroqui
Encarnación Fernández Ruiz
Juan Jesús Cruz-Hernández
Rogelio González-Sarmiento
author_facet Javier Fernández-Mateos
Raquel Seijas-Tamayo
Juan Carlos Adansa Klain
Miguel Pastor Borgoñón
Elisabeth Pérez-Ruiz
Ricard Mesía
Elvira del Barco
Carmen Salvador Coloma
Antonio Rueda Dominguez
Javier Caballero Daroqui
Encarnación Fernández Ruiz
Juan Jesús Cruz-Hernández
Rogelio González-Sarmiento
author_sort Javier Fernández-Mateos
title Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
title_short Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
title_full Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
title_fullStr Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
title_full_unstemmed Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
title_sort analysis of autophagy gene polymorphisms in spanish patients with head and neck squamous cell carcinoma
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2a6d4d6151124d12a8c1eba89b44d361
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