Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance

Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance

Hepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribu...

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Autores principales: Zhongliang Shen, Huijuan Yang, Sisi Yang, Wei Wang, Xiaoxian Cui, Xian Zhou, Wei Liu, Shaokun Pan, Yanfeng Liu, Junqi Zhang, Jiming Zhang, Youhua Xie, Jing Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2a6ebc55834f4e11b5c6b0b8ed9ae511
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spelling oai:doaj.org-article:2a6ebc55834f4e11b5c6b0b8ed9ae5112021-12-02T15:38:31ZHepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance10.1038/s41467-017-02304-72041-1723https://doaj.org/article/2a6ebc55834f4e11b5c6b0b8ed9ae5112017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02304-7https://doaj.org/toc/2041-1723Hepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribute to clearance.Zhongliang ShenHuijuan YangSisi YangWei WangXiaoxian CuiXian ZhouWei LiuShaokun PanYanfeng LiuJunqi ZhangJiming ZhangYouhua XieJing LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhongliang Shen
Huijuan Yang
Sisi Yang
Wei Wang
Xiaoxian Cui
Xian Zhou
Wei Liu
Shaokun Pan
Yanfeng Liu
Junqi Zhang
Jiming Zhang
Youhua Xie
Jing Liu
Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
description Hepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribute to clearance.
format article
author Zhongliang Shen
Huijuan Yang
Sisi Yang
Wei Wang
Xiaoxian Cui
Xian Zhou
Wei Liu
Shaokun Pan
Yanfeng Liu
Junqi Zhang
Jiming Zhang
Youhua Xie
Jing Liu
author_facet Zhongliang Shen
Huijuan Yang
Sisi Yang
Wei Wang
Xiaoxian Cui
Xian Zhou
Wei Liu
Shaokun Pan
Yanfeng Liu
Junqi Zhang
Jiming Zhang
Youhua Xie
Jing Liu
author_sort Zhongliang Shen
title Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_short Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_full Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_fullStr Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_full_unstemmed Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_sort hepatitis b virus persistence in mice reveals il-21 and il-33 as regulators of viral clearance
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2a6ebc55834f4e11b5c6b0b8ed9ae511
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