Motion correction in optoacoustic mesoscopy

Abstract Raster-scan optoacoustic mesoscopy (RSOM), also termed photoacoustic mesoscopy, offers novel insights into vascular morphology and pathophysiological biomarkers of skin inflammation in vivo at depths unattainable by other optical imaging methods. Using ultra-wideband detection and focused u...

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Autores principales:	Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a6f0e590f564516bd4db13d310eb630
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spelling	oai:doaj.org-article:2a6f0e590f564516bd4db13d310eb6302021-12-02T15:05:45ZMotion correction in optoacoustic mesoscopy10.1038/s41598-017-11277-y2045-2322https://doaj.org/article/2a6f0e590f564516bd4db13d310eb6302017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-11277-yhttps://doaj.org/toc/2045-2322Abstract Raster-scan optoacoustic mesoscopy (RSOM), also termed photoacoustic mesoscopy, offers novel insights into vascular morphology and pathophysiological biomarkers of skin inflammation in vivo at depths unattainable by other optical imaging methods. Using ultra-wideband detection and focused ultrasound transducers, RSOM can achieve axial resolution of 4 micron and lateral resolution of 20 micron to depths of several millimeters. However, motion effects may deteriorate performance and reduce the effective resolution. To provide high-quality optoacoustic images in clinical measurements, we developed a motion correction algorithm for RSOM. The algorithm is based on observing disruptions of the ultrasound wave front generated by the vertical movement of the melanin layer at the skin surface. From the disrupted skin surface, a smooth synthetic surface is generated, and the offset between the two surfaces is used to correct for the relative position of the ultrasound detector. We test the algorithm in measurements of healthy and psoriatic human skin and achieve effective resolution up to 5-fold higher than before correction. We discuss the performance of the correction algorithm and its implications in the context of multispectral mesoscopy.Mathias SchwarzNatalie Garzorz-StarkKilian EyerichJuan AguirreVasilis NtziachristosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mathias Schwarz Natalie Garzorz-Stark Kilian Eyerich Juan Aguirre Vasilis Ntziachristos Motion correction in optoacoustic mesoscopy
description	Abstract Raster-scan optoacoustic mesoscopy (RSOM), also termed photoacoustic mesoscopy, offers novel insights into vascular morphology and pathophysiological biomarkers of skin inflammation in vivo at depths unattainable by other optical imaging methods. Using ultra-wideband detection and focused ultrasound transducers, RSOM can achieve axial resolution of 4 micron and lateral resolution of 20 micron to depths of several millimeters. However, motion effects may deteriorate performance and reduce the effective resolution. To provide high-quality optoacoustic images in clinical measurements, we developed a motion correction algorithm for RSOM. The algorithm is based on observing disruptions of the ultrasound wave front generated by the vertical movement of the melanin layer at the skin surface. From the disrupted skin surface, a smooth synthetic surface is generated, and the offset between the two surfaces is used to correct for the relative position of the ultrasound detector. We test the algorithm in measurements of healthy and psoriatic human skin and achieve effective resolution up to 5-fold higher than before correction. We discuss the performance of the correction algorithm and its implications in the context of multispectral mesoscopy.
format	article
author	Mathias Schwarz Natalie Garzorz-Stark Kilian Eyerich Juan Aguirre Vasilis Ntziachristos
author_facet	Mathias Schwarz Natalie Garzorz-Stark Kilian Eyerich Juan Aguirre Vasilis Ntziachristos
author_sort	Mathias Schwarz
title	Motion correction in optoacoustic mesoscopy
title_short	Motion correction in optoacoustic mesoscopy
title_full	Motion correction in optoacoustic mesoscopy
title_fullStr	Motion correction in optoacoustic mesoscopy
title_full_unstemmed	Motion correction in optoacoustic mesoscopy
title_sort	motion correction in optoacoustic mesoscopy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2a6f0e590f564516bd4db13d310eb630
work_keys_str_mv	AT mathiasschwarz motioncorrectioninoptoacousticmesoscopy AT nataliegarzorzstark motioncorrectioninoptoacousticmesoscopy AT kilianeyerich motioncorrectioninoptoacousticmesoscopy AT juanaguirre motioncorrectioninoptoacousticmesoscopy AT vasilisntziachristos motioncorrectioninoptoacousticmesoscopy
_version_	1718388693396357120

Motion correction in optoacoustic mesoscopy

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