Chemokine profile in women with moderate to severe anxiety and depression during pregnancy

Abstract Background Cytokine levels have been extensively described in pregnant subjects under normal and pathological conditions, including mood-related disorders. Concerning chemokines, very few studies have reported their association with psychiatric disorders during pregnancy. Therefore, we expl...

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Autores principales:	Ignacio Camacho-Arroyo, Mónica Flores-Ramos, Ismael Mancilla-Herrera, Fausto Moisés Coronel Cruz, Joselin Hernández-Ruiz, Gabriela Pellón Diaz, Blanca Farfán Labonne, María del Pilar Meza-Rodríguez, Philippe Leff Gelman
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chemokines Inflammation Immune response Pregnancy Depression Anxiety Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/2a7016c465e149fdbf3db033125a14f7
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spelling	oai:doaj.org-article:2a7016c465e149fdbf3db033125a14f72021-12-05T12:20:46ZChemokine profile in women with moderate to severe anxiety and depression during pregnancy10.1186/s12884-021-04225-21471-2393https://doaj.org/article/2a7016c465e149fdbf3db033125a14f72021-12-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04225-2https://doaj.org/toc/1471-2393Abstract Background Cytokine levels have been extensively described in pregnant subjects under normal and pathological conditions, including mood-related disorders. Concerning chemokines, very few studies have reported their association with psychiatric disorders during pregnancy. Therefore, we explored the chemokine profile in women exhibiting anxiety and depression during late pregnancy in the present study. Methods One hundred twenty-six pregnant women in the 3rd trimester of pregnancy, displaying moderate to severe anxiety (ANX) alone and women exhibiting moderate to severe anxiety with comorbid depression (ANX + DEP), and 40 control pregnant women without affective disorders (CTRL) were evaluated through the Hamilton Anxiety Rating Scale (HARS) and the Hamilton Depression Rating Scale (HDRS). Serum chemokine levels of MCP-1 (CCL2), RANTES (CCL5), IP-10 (CXCL10), Eotaxin (CCL11), TARC (CCL17), MIP-1α (CCL3), MIP-1β (CCL4), MIG (CXCL9), MIP-3α (CCL20), ENA-78 (CXCL5), GROα (CXCL1), I-TAC (CXCL11) and IL-8 (CXCL8)] were measured by immunoassay. Clinical, biochemical, and sociodemographic parameters were correlated with HARS and HDRS score values. Results Serum levels of most chemokines were significantly higher in the ANX and in the ANX + DEP groups, when compared to the CTRL group. Positive correlations were observed between MIP-1α/CCL3, MIP-1β/CCL4, MCP-1/CCL2, MIP-3α/CCL20, RANTES/CCL5, Eotaxin/CCL11, and I-TAC/CXCL11 with high scores for anxiety (HARS) (p < 0.05) and for depression (HDRS) (p < 0.004). After controlling clinical measures for age + gwk + BMI, chemokines such as IL-8/CXCL8, MCP-1/CCL2 and MIP-1β/CCL4 were found associated with high scores for anxiety (p < 0.05) in the ANX group. TARC/CCL17 and Eotaxin/CCL11 showed significant associations with high scores for depression (p < 0.04) whereas, MCP-1/CCL2 and MIP-1α/CCL3 were significantly associated with high scores for anxiety (p < 0.05) in the ANX + DEP group. Using a multivariate linear model, high serum levels of MIP-1β/CCL4 and Eotaxin/CCL11 remained associated with depression (p < 0.01), while, IL-8/CXCL8, MIP-1β/CCL4, MCP-1/CCL2, and MIP-1α/CCL3 were associated with anxiety (p < 0.05) in the symptomatic groups. Conclusions Our data show that serum levels of distinct chemokines are increased in women exhibiting high levels of affective symptoms during late pregnancy. Our results suggest that increased levels of anxiety, depressive symptoms, and mood-related disorders may promote changes in specific functional chemokines associated with a chronic inflammatory process. If not controlled, it may lead to adverse obstetric and negative neonate outcomes, child development and neuropsychiatric alterations in the postnatal life. Highlights Chemokine levels increase in affective disorders during pregnancy.Ignacio Camacho-ArroyoMónica Flores-RamosIsmael Mancilla-HerreraFausto Moisés Coronel CruzJoselin Hernández-RuizGabriela Pellón DiazBlanca Farfán LabonneMaría del Pilar Meza-RodríguezPhilippe Leff GelmanBMCarticleChemokinesInflammationImmune responsePregnancyDepressionAnxietyGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemokines Inflammation Immune response Pregnancy Depression Anxiety Gynecology and obstetrics RG1-991
spellingShingle	Chemokines Inflammation Immune response Pregnancy Depression Anxiety Gynecology and obstetrics RG1-991 Ignacio Camacho-Arroyo Mónica Flores-Ramos Ismael Mancilla-Herrera Fausto Moisés Coronel Cruz Joselin Hernández-Ruiz Gabriela Pellón Diaz Blanca Farfán Labonne María del Pilar Meza-Rodríguez Philippe Leff Gelman Chemokine profile in women with moderate to severe anxiety and depression during pregnancy
description	Abstract Background Cytokine levels have been extensively described in pregnant subjects under normal and pathological conditions, including mood-related disorders. Concerning chemokines, very few studies have reported their association with psychiatric disorders during pregnancy. Therefore, we explored the chemokine profile in women exhibiting anxiety and depression during late pregnancy in the present study. Methods One hundred twenty-six pregnant women in the 3rd trimester of pregnancy, displaying moderate to severe anxiety (ANX) alone and women exhibiting moderate to severe anxiety with comorbid depression (ANX + DEP), and 40 control pregnant women without affective disorders (CTRL) were evaluated through the Hamilton Anxiety Rating Scale (HARS) and the Hamilton Depression Rating Scale (HDRS). Serum chemokine levels of MCP-1 (CCL2), RANTES (CCL5), IP-10 (CXCL10), Eotaxin (CCL11), TARC (CCL17), MIP-1α (CCL3), MIP-1β (CCL4), MIG (CXCL9), MIP-3α (CCL20), ENA-78 (CXCL5), GROα (CXCL1), I-TAC (CXCL11) and IL-8 (CXCL8)] were measured by immunoassay. Clinical, biochemical, and sociodemographic parameters were correlated with HARS and HDRS score values. Results Serum levels of most chemokines were significantly higher in the ANX and in the ANX + DEP groups, when compared to the CTRL group. Positive correlations were observed between MIP-1α/CCL3, MIP-1β/CCL4, MCP-1/CCL2, MIP-3α/CCL20, RANTES/CCL5, Eotaxin/CCL11, and I-TAC/CXCL11 with high scores for anxiety (HARS) (p < 0.05) and for depression (HDRS) (p < 0.004). After controlling clinical measures for age + gwk + BMI, chemokines such as IL-8/CXCL8, MCP-1/CCL2 and MIP-1β/CCL4 were found associated with high scores for anxiety (p < 0.05) in the ANX group. TARC/CCL17 and Eotaxin/CCL11 showed significant associations with high scores for depression (p < 0.04) whereas, MCP-1/CCL2 and MIP-1α/CCL3 were significantly associated with high scores for anxiety (p < 0.05) in the ANX + DEP group. Using a multivariate linear model, high serum levels of MIP-1β/CCL4 and Eotaxin/CCL11 remained associated with depression (p < 0.01), while, IL-8/CXCL8, MIP-1β/CCL4, MCP-1/CCL2, and MIP-1α/CCL3 were associated with anxiety (p < 0.05) in the symptomatic groups. Conclusions Our data show that serum levels of distinct chemokines are increased in women exhibiting high levels of affective symptoms during late pregnancy. Our results suggest that increased levels of anxiety, depressive symptoms, and mood-related disorders may promote changes in specific functional chemokines associated with a chronic inflammatory process. If not controlled, it may lead to adverse obstetric and negative neonate outcomes, child development and neuropsychiatric alterations in the postnatal life. Highlights Chemokine levels increase in affective disorders during pregnancy.
format	article
author	Ignacio Camacho-Arroyo Mónica Flores-Ramos Ismael Mancilla-Herrera Fausto Moisés Coronel Cruz Joselin Hernández-Ruiz Gabriela Pellón Diaz Blanca Farfán Labonne María del Pilar Meza-Rodríguez Philippe Leff Gelman
author_facet	Ignacio Camacho-Arroyo Mónica Flores-Ramos Ismael Mancilla-Herrera Fausto Moisés Coronel Cruz Joselin Hernández-Ruiz Gabriela Pellón Diaz Blanca Farfán Labonne María del Pilar Meza-Rodríguez Philippe Leff Gelman
author_sort	Ignacio Camacho-Arroyo
title	Chemokine profile in women with moderate to severe anxiety and depression during pregnancy
title_short	Chemokine profile in women with moderate to severe anxiety and depression during pregnancy
title_full	Chemokine profile in women with moderate to severe anxiety and depression during pregnancy
title_fullStr	Chemokine profile in women with moderate to severe anxiety and depression during pregnancy
title_full_unstemmed	Chemokine profile in women with moderate to severe anxiety and depression during pregnancy
title_sort	chemokine profile in women with moderate to severe anxiety and depression during pregnancy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/2a7016c465e149fdbf3db033125a14f7
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Chemokine profile in women with moderate to severe anxiety and depression during pregnancy

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