Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus

Wei-Shuo Zhang,1 Xiao-Ou Li,1 Hui Zhang,2 Chun Gao,1 Long Fang,1 Hua-Yuan Yang1 1Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, People’s Republic of China; 2Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical Unive...

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Autores principales:	Zhang WS, Li XO, Zhang H, Gao C, Fang L, Yang HY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hepatocellular carcinoma diabetes mellitus systolic blood pressure Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2a78d312ff4b4df0bbf2cdcb724982ca
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spelling	oai:doaj.org-article:2a78d312ff4b4df0bbf2cdcb724982ca2021-12-02T10:27:07ZIncreased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus1178-7007https://doaj.org/article/2a78d312ff4b4df0bbf2cdcb724982ca2020-06-01T00:00:00Zhttps://www.dovepress.com/increased-level-of-systolic-blood-pressure-in-hepatocellular-carcinoma-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Wei-Shuo Zhang,1 Xiao-Ou Li,1 Hui Zhang,2 Chun Gao,1 Long Fang,1 Hua-Yuan Yang1 1Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, People’s Republic of China; 2Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, People’s Republic of ChinaCorrespondence: Chun GaoDepartment of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, People’s Republic of ChinaTel/Fax +86-10-84205503Email gaochun@bjmu.edu.cnBackground: More than 50% of patients with type 2 diabetes mellitus (DM) also have hypertension. Moreover, hypertension has been regarded as one paraneoplastic phenomenon of hepatocellular carcinoma (HCC). Our study was designed to determine the relationship between blood pressure and DM in HCC patients.Patients and Methods: A total of 879 HCC patients were included and 151 (17.2%) were diagnosed with DM. Multivariable logistic regression analysis was used to determine the relationship and the results were expressed as adjusted odds ratios (AORs) and their 95% confidence intervals (CIs). Considering the effect of potential confounders, sub-group analysis was performed. We would further study the association of systolic blood pressure (SBP) with fasting glucose, and the association between DM duration/treatment and SBP level.Results: Compared with non-diabetic patients, the diabetic patients had increased levels of SBP (133.7± 18.5 mmHg vs 128.3± 15.2 mmHg, P=0.001) and fasting blood glucose (9.13± 3.04 mmol/L vs 5.18± 1.08 mmol/L, P< 0.001), an elder age (58.5± 10.2 years vs 55.3± 11.2 years, P=0.001), a higher percentage of cirrhosis diagnosis (60.9% vs 48.2%, P=0.004), lower percentages of drinking (18.5% vs 30.8%, P=0.002) and smoking (30.5% vs 43.7%, P=0.003), and decreased levels of GGT (median/interquartile-range 88/53-177 U/L vs 117/58-248 U/L, P=0.037), platelet count (121.4± 76.6 × 109/L vs 151.2± 82.8 × 109/L, P< 0.001) and hemoglobin (124.3± 25.5 g/L vs 133.6± 24.2 g/L, P< 0.001). Multivariable analysis showed that, statistically significant differences were found for SBP ≥ 140 mmHg (AOR=2.101; 95% CI, 1.424– 3.100; P< 0.001), smoking (AOR=0.637; 95% CI, 0.415– 0.979; P=0.040), hemoglobin (AOR=0.990; 95% CI, 0.983– 0.998; P=0.010) and platelet count (AOR=0.996; 95% CI, 0.994– 0.999; P=0.009). For the relationship between SBP and DM, the positive result was supported by most (10/14) of the subgroup analyses.Conclusion: SBP level was increased in HCC patients with diabetes mellitus.Keywords: hepatocellular carcinoma, diabetes mellitus, systolic blood pressureZhang WSLi XOZhang HGao CFang LYang HYDove Medical Pressarticlehepatocellular carcinomadiabetes mellitussystolic blood pressureSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1979-1988 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma diabetes mellitus systolic blood pressure Specialties of internal medicine RC581-951
spellingShingle	hepatocellular carcinoma diabetes mellitus systolic blood pressure Specialties of internal medicine RC581-951 Zhang WS Li XO Zhang H Gao C Fang L Yang HY Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus
description	Wei-Shuo Zhang,1 Xiao-Ou Li,1 Hui Zhang,2 Chun Gao,1 Long Fang,1 Hua-Yuan Yang1 1Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, People’s Republic of China; 2Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, People’s Republic of ChinaCorrespondence: Chun GaoDepartment of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, People’s Republic of ChinaTel/Fax +86-10-84205503Email gaochun@bjmu.edu.cnBackground: More than 50% of patients with type 2 diabetes mellitus (DM) also have hypertension. Moreover, hypertension has been regarded as one paraneoplastic phenomenon of hepatocellular carcinoma (HCC). Our study was designed to determine the relationship between blood pressure and DM in HCC patients.Patients and Methods: A total of 879 HCC patients were included and 151 (17.2%) were diagnosed with DM. Multivariable logistic regression analysis was used to determine the relationship and the results were expressed as adjusted odds ratios (AORs) and their 95% confidence intervals (CIs). Considering the effect of potential confounders, sub-group analysis was performed. We would further study the association of systolic blood pressure (SBP) with fasting glucose, and the association between DM duration/treatment and SBP level.Results: Compared with non-diabetic patients, the diabetic patients had increased levels of SBP (133.7± 18.5 mmHg vs 128.3± 15.2 mmHg, P=0.001) and fasting blood glucose (9.13± 3.04 mmol/L vs 5.18± 1.08 mmol/L, P< 0.001), an elder age (58.5± 10.2 years vs 55.3± 11.2 years, P=0.001), a higher percentage of cirrhosis diagnosis (60.9% vs 48.2%, P=0.004), lower percentages of drinking (18.5% vs 30.8%, P=0.002) and smoking (30.5% vs 43.7%, P=0.003), and decreased levels of GGT (median/interquartile-range 88/53-177 U/L vs 117/58-248 U/L, P=0.037), platelet count (121.4± 76.6 × 109/L vs 151.2± 82.8 × 109/L, P< 0.001) and hemoglobin (124.3± 25.5 g/L vs 133.6± 24.2 g/L, P< 0.001). Multivariable analysis showed that, statistically significant differences were found for SBP ≥ 140 mmHg (AOR=2.101; 95% CI, 1.424– 3.100; P< 0.001), smoking (AOR=0.637; 95% CI, 0.415– 0.979; P=0.040), hemoglobin (AOR=0.990; 95% CI, 0.983– 0.998; P=0.010) and platelet count (AOR=0.996; 95% CI, 0.994– 0.999; P=0.009). For the relationship between SBP and DM, the positive result was supported by most (10/14) of the subgroup analyses.Conclusion: SBP level was increased in HCC patients with diabetes mellitus.Keywords: hepatocellular carcinoma, diabetes mellitus, systolic blood pressure
format	article
author	Zhang WS Li XO Zhang H Gao C Fang L Yang HY
author_facet	Zhang WS Li XO Zhang H Gao C Fang L Yang HY
author_sort	Zhang WS
title	Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus
title_short	Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus
title_full	Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus
title_fullStr	Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus
title_full_unstemmed	Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus
title_sort	increased level of systolic blood pressure in hepatocellular carcinoma patients with diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2a78d312ff4b4df0bbf2cdcb724982ca
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Increased Level of Systolic Blood Pressure in Hepatocellular Carcinoma Patients with Diabetes Mellitus

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