Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer stability ameliorating the disease phenotype.
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Nature Portfolio
2020
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oai:doaj.org-article:2a79c2c4685b4d2598d773092d995d7b2021-12-02T16:25:00ZRetromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis10.1038/s41467-020-17524-72041-1723https://doaj.org/article/2a79c2c4685b4d2598d773092d995d7b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17524-7https://doaj.org/toc/2041-1723ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer stability ameliorating the disease phenotype.Luca MuzioRiccardo SirtoriDavide GornatiSimona EleuteriAndrea FossaghiDiego BrancaccioLeonardo ManzoniLinda OttoboniLuca De FeoAngelo QuattriniEloise MastrangeloLuca SorrentinoEmanuele ScaloneGiancarlo ComiLuciana MarinelliNilo RivaMario MilaniPierfausto SeneciGianvito MartinoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Luca Muzio Riccardo Sirtori Davide Gornati Simona Eleuteri Andrea Fossaghi Diego Brancaccio Leonardo Manzoni Linda Ottoboni Luca De Feo Angelo Quattrini Eloise Mastrangelo Luca Sorrentino Emanuele Scalone Giancarlo Comi Luciana Marinelli Nilo Riva Mario Milani Pierfausto Seneci Gianvito Martino Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis |
| description |
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer stability ameliorating the disease phenotype. |
| format |
article |
| author |
Luca Muzio Riccardo Sirtori Davide Gornati Simona Eleuteri Andrea Fossaghi Diego Brancaccio Leonardo Manzoni Linda Ottoboni Luca De Feo Angelo Quattrini Eloise Mastrangelo Luca Sorrentino Emanuele Scalone Giancarlo Comi Luciana Marinelli Nilo Riva Mario Milani Pierfausto Seneci Gianvito Martino |
| author_facet |
Luca Muzio Riccardo Sirtori Davide Gornati Simona Eleuteri Andrea Fossaghi Diego Brancaccio Leonardo Manzoni Linda Ottoboni Luca De Feo Angelo Quattrini Eloise Mastrangelo Luca Sorrentino Emanuele Scalone Giancarlo Comi Luciana Marinelli Nilo Riva Mario Milani Pierfausto Seneci Gianvito Martino |
| author_sort |
Luca Muzio |
| title |
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis |
| title_short |
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis |
| title_full |
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis |
| title_fullStr |
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis |
| title_full_unstemmed |
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis |
| title_sort |
retromer stabilization results in neuroprotection in a model of amyotrophic lateral sclerosis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/2a79c2c4685b4d2598d773092d995d7b |
| work_keys_str_mv |
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| _version_ |
1718384041098477568 |