CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab

Alessio Gambardella,1 Gaetano Licata,1 Giulia Calabrese,1 Alina De Rosa,1 Francesca Pagliuca,2 Roberto Alfano,3 Giuseppe Argenziano1 1Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, De...

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Autores principales:	Gambardella A, Licata G, Calabrese G, De Rosa A, Pagliuca F, Alfano R, Argenziano G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	immune-mediated inflammatory diseases biological therapy anti-tnf-α therapy cytomegalovirus psoriasis case report Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/2a7ac0d2ef5c47ea82d701a73c7ac35b
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spelling	oai:doaj.org-article:2a7ac0d2ef5c47ea82d701a73c7ac35b2021-12-02T12:17:06ZCMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab2230-326Xhttps://doaj.org/article/2a7ac0d2ef5c47ea82d701a73c7ac35b2020-11-01T00:00:00Zhttps://www.dovepress.com/cmv-infection-a-clinical-challenge-in-biological-therapy-the-case-of-a-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XAlessio Gambardella,1 Gaetano Licata,1 Giulia Calabrese,1 Alina De Rosa,1 Francesca Pagliuca,2 Roberto Alfano,3 Giuseppe Argenziano1 1Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 3Department of Anesthesiology, Surgery and Emergency, University of Campania Luigi Vanvitelli, Naples, ItalyCorrespondence: Gaetano LicataDepartment of Dermatology, University of Campania “Luigi Vanvitelli”, Via Sergio Pansini, 5, Napoli 80131, ItalyTel +39 081 5666828Fax +39 081 546 87 59Email gaetano.licata89@gmail.comAbstract: The use of biological therapy is now common practice in the treatment of immune-mediated inflammatory diseases (IMID). Currently, there are no guidelines related to the management of cytomegalovirus (CMV) infections or reactivation during therapy with biological agents. Furthermore, there is a lack of guidance on the management of asymptomatic patients with persistent positive immunoglobulin (Ig)M anti-CMV after an extended period and who have to undergo therapy with biological agents. We report the case of a patient in this situation for whom treatment with biological drugs for psoriasis was indicated. A good clinical response was obtained with secukinumab and maintained during 6 months of follow-up. No infectious disease or reactivation of CMV infection occurred. We suggest some possible guidelines for the management of such cases.Keywords: immune-mediated inflammatory diseases, biological therapy, anti-TNF-α therapy, cytomegalovirus, psoriasis, case reportGambardella ALicata GCalabrese GDe Rosa APagliuca FAlfano RArgenziano GDove Medical Pressarticleimmune-mediated inflammatory diseasesbiological therapyanti-tnf-α therapycytomegaloviruspsoriasiscase reportDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 10, Pp 57-60 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	immune-mediated inflammatory diseases biological therapy anti-tnf-α therapy cytomegalovirus psoriasis case report Dermatology RL1-803
spellingShingle	immune-mediated inflammatory diseases biological therapy anti-tnf-α therapy cytomegalovirus psoriasis case report Dermatology RL1-803 Gambardella A Licata G Calabrese G De Rosa A Pagliuca F Alfano R Argenziano G CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab
description	Alessio Gambardella,1 Gaetano Licata,1 Giulia Calabrese,1 Alina De Rosa,1 Francesca Pagliuca,2 Roberto Alfano,3 Giuseppe Argenziano1 1Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 3Department of Anesthesiology, Surgery and Emergency, University of Campania Luigi Vanvitelli, Naples, ItalyCorrespondence: Gaetano LicataDepartment of Dermatology, University of Campania “Luigi Vanvitelli”, Via Sergio Pansini, 5, Napoli 80131, ItalyTel +39 081 5666828Fax +39 081 546 87 59Email gaetano.licata89@gmail.comAbstract: The use of biological therapy is now common practice in the treatment of immune-mediated inflammatory diseases (IMID). Currently, there are no guidelines related to the management of cytomegalovirus (CMV) infections or reactivation during therapy with biological agents. Furthermore, there is a lack of guidance on the management of asymptomatic patients with persistent positive immunoglobulin (Ig)M anti-CMV after an extended period and who have to undergo therapy with biological agents. We report the case of a patient in this situation for whom treatment with biological drugs for psoriasis was indicated. A good clinical response was obtained with secukinumab and maintained during 6 months of follow-up. No infectious disease or reactivation of CMV infection occurred. We suggest some possible guidelines for the management of such cases.Keywords: immune-mediated inflammatory diseases, biological therapy, anti-TNF-α therapy, cytomegalovirus, psoriasis, case report
format	article
author	Gambardella A Licata G Calabrese G De Rosa A Pagliuca F Alfano R Argenziano G
author_facet	Gambardella A Licata G Calabrese G De Rosa A Pagliuca F Alfano R Argenziano G
author_sort	Gambardella A
title	CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab
title_short	CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab
title_full	CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab
title_fullStr	CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab
title_full_unstemmed	CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab
title_sort	cmv infection: a clinical challenge in biological therapy? the case of asymptomatic patients with persistent positive immunoglobulin m anti-cmv treated with secukinumab
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2a7ac0d2ef5c47ea82d701a73c7ac35b
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CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab

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