Joint analysis of expression levels and histological images identifies genes associated with tissue morphology

Image features from histological slides can be used as informative endophenotypes in association studies for tissue-localized pathologies. Here, the authors develop ImageCCA, a framework for joint analysis of paired gene expression and histology data derived from automatically extracted image featur...

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Autores principales:	Jordan T. Ash, Gregory Darnell, Daniel Munro, Barbara E. Engelhardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a7e696055bd421b97061786f145137f
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spelling	oai:doaj.org-article:2a7e696055bd421b97061786f145137f2021-12-02T13:32:54ZJoint analysis of expression levels and histological images identifies genes associated with tissue morphology10.1038/s41467-021-21727-x2041-1723https://doaj.org/article/2a7e696055bd421b97061786f145137f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21727-xhttps://doaj.org/toc/2041-1723Image features from histological slides can be used as informative endophenotypes in association studies for tissue-localized pathologies. Here, the authors develop ImageCCA, a framework for joint analysis of paired gene expression and histology data derived from automatically extracted image features.Jordan T. AshGregory DarnellDaniel MunroBarbara E. EngelhardtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordan T. Ash Gregory Darnell Daniel Munro Barbara E. Engelhardt Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
description	Image features from histological slides can be used as informative endophenotypes in association studies for tissue-localized pathologies. Here, the authors develop ImageCCA, a framework for joint analysis of paired gene expression and histology data derived from automatically extracted image features.
format	article
author	Jordan T. Ash Gregory Darnell Daniel Munro Barbara E. Engelhardt
author_facet	Jordan T. Ash Gregory Darnell Daniel Munro Barbara E. Engelhardt
author_sort	Jordan T. Ash
title	Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
title_short	Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
title_full	Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
title_fullStr	Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
title_full_unstemmed	Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
title_sort	joint analysis of expression levels and histological images identifies genes associated with tissue morphology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a7e696055bd421b97061786f145137f
work_keys_str_mv	AT jordantash jointanalysisofexpressionlevelsandhistologicalimagesidentifiesgenesassociatedwithtissuemorphology AT gregorydarnell jointanalysisofexpressionlevelsandhistologicalimagesidentifiesgenesassociatedwithtissuemorphology AT danielmunro jointanalysisofexpressionlevelsandhistologicalimagesidentifiesgenesassociatedwithtissuemorphology AT barbaraeengelhardt jointanalysisofexpressionlevelsandhistologicalimagesidentifiesgenesassociatedwithtissuemorphology
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Joint analysis of expression levels and histological images identifies genes associated with tissue morphology

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