Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls

Çiğdem Yektaş,1 Merve Alpay,2 Ali Evren Tufan31Department of Child and Adolescent Psychiatry, Düzce Üniversitesi, Düzce, Turkey; 2Department of Medical Biochemistry, Faculty of Medicine, Düzce Üniversitesi, Düzce, Turkey; 3Department o...

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Autores principales:	Yektaş Ç, Alpay M, Tufan AE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	vitamin B12 folate homocysteine attention-deficit/ hyperactivity disorder autism spectrum disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2a7fd1adcde0454fa80903c4390ab88c
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spelling	oai:doaj.org-article:2a7fd1adcde0454fa80903c4390ab88c2021-12-02T01:35:22ZComparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls1178-2021https://doaj.org/article/2a7fd1adcde0454fa80903c4390ab88c2019-08-01T00:00:00Zhttps://www.dovepress.com/comparison-of-serum-b12-folate-and-homocysteine-concentrations-in-chil-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Çiğdem Yektaş,1 Merve Alpay,2 Ali Evren Tufan31Department of Child and Adolescent Psychiatry, Düzce Üniversitesi, Düzce, Turkey; 2Department of Medical Biochemistry, Faculty of Medicine, Düzce Üniversitesi, Düzce, Turkey; 3Department of Child and Adolescent Psychiatry, Acıbadem Üniversitesi Tıp Fakültesi, Istanbul, TurkeyObjective: We aimed to investigate the serum concentrations of vitamin B12, folate and homocysteine in children diagnosed with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and healthy controls.Materials and methods: Serum vitamin B12, folate and homocysteine concentrations were measured in 118 children (48 children diagnosed with ADHD, 35 children diagnosed with ASD and 35 healthy controls). Symptom severity in the ADHD and ASD groups was evaluated by the Childhood Autism Rating Scale and Turgay-DSM-IV-Based Screening and Assessment Scale for Disruptive Behavior Disorders. Multivariate analysis of covariance was used to evaluate the effects of diagnosis and gender on biochemical parameters.Results: The ADHD and ASD groups and the healthy controls differed significantly regarding vitamin B12 and homocysteine concentrations, but not folate levels. Patients with ASD had the lowest vitamin B12 and the highest homocysteine levels. Vitamin B12 levels correlated negatively with hyperactivity and/orimpulsivity and oppositionality symptoms in children with ADHD. There were no relationships between psychometric evaluations and laboratory measurements in children with ASD. Gender did not affect vitamin concentrations.Conclusion: Previous studies found that vitamin B12 was reduced while homocysteine was elevated among patients with ADHD and ASDs. Our results also support those reported previously. Oppositionality and hyperactivity and/orimpulsivity may be related to vitamin B12 and homocysteine levels in children with ADHD. Further studies are required to define the role of these parameters and effects on the etiology and clinical manifestations of ASD and ADHD.Keywords: vitamin B12, folate, homocysteine, attention deficit hyperactivity disorder, autism spectrum disorderYektaş ÇAlpay MTufan AEDove Medical Pressarticlevitamin B12folatehomocysteineattention-deficit/ hyperactivity disorderautism spectrum disordersNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2213-2219 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin B12 folate homocysteine attention-deficit/ hyperactivity disorder autism spectrum disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	vitamin B12 folate homocysteine attention-deficit/ hyperactivity disorder autism spectrum disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yektaş Ç Alpay M Tufan AE Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls
description	Çiğdem Yektaş,1 Merve Alpay,2 Ali Evren Tufan31Department of Child and Adolescent Psychiatry, Düzce Üniversitesi, Düzce, Turkey; 2Department of Medical Biochemistry, Faculty of Medicine, Düzce Üniversitesi, Düzce, Turkey; 3Department of Child and Adolescent Psychiatry, Acıbadem Üniversitesi Tıp Fakültesi, Istanbul, TurkeyObjective: We aimed to investigate the serum concentrations of vitamin B12, folate and homocysteine in children diagnosed with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and healthy controls.Materials and methods: Serum vitamin B12, folate and homocysteine concentrations were measured in 118 children (48 children diagnosed with ADHD, 35 children diagnosed with ASD and 35 healthy controls). Symptom severity in the ADHD and ASD groups was evaluated by the Childhood Autism Rating Scale and Turgay-DSM-IV-Based Screening and Assessment Scale for Disruptive Behavior Disorders. Multivariate analysis of covariance was used to evaluate the effects of diagnosis and gender on biochemical parameters.Results: The ADHD and ASD groups and the healthy controls differed significantly regarding vitamin B12 and homocysteine concentrations, but not folate levels. Patients with ASD had the lowest vitamin B12 and the highest homocysteine levels. Vitamin B12 levels correlated negatively with hyperactivity and/orimpulsivity and oppositionality symptoms in children with ADHD. There were no relationships between psychometric evaluations and laboratory measurements in children with ASD. Gender did not affect vitamin concentrations.Conclusion: Previous studies found that vitamin B12 was reduced while homocysteine was elevated among patients with ADHD and ASDs. Our results also support those reported previously. Oppositionality and hyperactivity and/orimpulsivity may be related to vitamin B12 and homocysteine levels in children with ADHD. Further studies are required to define the role of these parameters and effects on the etiology and clinical manifestations of ASD and ADHD.Keywords: vitamin B12, folate, homocysteine, attention deficit hyperactivity disorder, autism spectrum disorder
format	article
author	Yektaş Ç Alpay M Tufan AE
author_facet	Yektaş Ç Alpay M Tufan AE
author_sort	Yektaş Ç
title	Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls
title_short	Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls
title_full	Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls
title_fullStr	Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls
title_full_unstemmed	Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls
title_sort	comparison of serum b12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2a7fd1adcde0454fa80903c4390ab88c
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_version_	1718402946542075904

Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls

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