Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing

Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing

Serum-resistant bacteria can escape complement killing in the bloodstream. Here, using metabolomics and metabolite perturbations, the authors describe an altered metabolic state in serum-resistant Escherichia coli and show that exogenous glycine potentiates elimination of pathogenic bacteria in vivo...

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Autores principales: Zhi-xue Cheng, Chang Guo, Zhuang-gui Chen, Tian-ci Yang, Jian-ying Zhang, Jie Wang, Jia-xin Zhu, Dan Li, Tian-tuo Zhang, Hui Li, Bo Peng, Xuan-xian Peng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/2a81a06532b8422685249d3fbec16fbf
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spelling oai:doaj.org-article:2a81a06532b8422685249d3fbec16fbf2021-12-02T14:38:46ZGlycine, serine and threonine metabolism confounds efficacy of complement-mediated killing10.1038/s41467-019-11129-52041-1723https://doaj.org/article/2a81a06532b8422685249d3fbec16fbf2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11129-5https://doaj.org/toc/2041-1723Serum-resistant bacteria can escape complement killing in the bloodstream. Here, using metabolomics and metabolite perturbations, the authors describe an altered metabolic state in serum-resistant Escherichia coli and show that exogenous glycine potentiates elimination of pathogenic bacteria in vivo.Zhi-xue ChengChang GuoZhuang-gui ChenTian-ci YangJian-ying ZhangJie WangJia-xin ZhuDan LiTian-tuo ZhangHui LiBo PengXuan-xian PengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhi-xue Cheng
Chang Guo
Zhuang-gui Chen
Tian-ci Yang
Jian-ying Zhang
Jie Wang
Jia-xin Zhu
Dan Li
Tian-tuo Zhang
Hui Li
Bo Peng
Xuan-xian Peng
Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
description Serum-resistant bacteria can escape complement killing in the bloodstream. Here, using metabolomics and metabolite perturbations, the authors describe an altered metabolic state in serum-resistant Escherichia coli and show that exogenous glycine potentiates elimination of pathogenic bacteria in vivo.
format article
author Zhi-xue Cheng
Chang Guo
Zhuang-gui Chen
Tian-ci Yang
Jian-ying Zhang
Jie Wang
Jia-xin Zhu
Dan Li
Tian-tuo Zhang
Hui Li
Bo Peng
Xuan-xian Peng
author_facet Zhi-xue Cheng
Chang Guo
Zhuang-gui Chen
Tian-ci Yang
Jian-ying Zhang
Jie Wang
Jia-xin Zhu
Dan Li
Tian-tuo Zhang
Hui Li
Bo Peng
Xuan-xian Peng
author_sort Zhi-xue Cheng
title Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
title_short Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
title_full Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
title_fullStr Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
title_full_unstemmed Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
title_sort glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2a81a06532b8422685249d3fbec16fbf
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