Epromoters function as a hub to recruit key transcription factors required for the inflammatory response

Some promoters, termed Epromoters, can display enhancer activity and regulate distal genes in their endogenous context. Here the authors report the broad involvement of Epromoters in the coordinated activation of interferon (IFN) response. They show activation of a number of IFN-inducible genes is a...

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Autores principales:	David Santiago-Algarra, Charbel Souaid, Himanshu Singh, Lan T. M. Dao, Saadat Hussain, Alejandra Medina-Rivera, Lucia Ramirez-Navarro, Jaime A. Castro-Mondragon, Nori Sadouni, Guillaume Charbonnier, Salvatore Spicuglia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a838a6dac1c4a42aac0c04facbcf0f8
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spelling	oai:doaj.org-article:2a838a6dac1c4a42aac0c04facbcf0f82021-11-21T12:36:08ZEpromoters function as a hub to recruit key transcription factors required for the inflammatory response10.1038/s41467-021-26861-02041-1723https://doaj.org/article/2a838a6dac1c4a42aac0c04facbcf0f82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26861-0https://doaj.org/toc/2041-1723Some promoters, termed Epromoters, can display enhancer activity and regulate distal genes in their endogenous context. Here the authors report the broad involvement of Epromoters in the coordinated activation of interferon (IFN) response. They show activation of a number of IFN-inducible genes is a result of Epromoters regulating expression of an entire IFN response gene cluster.David Santiago-AlgarraCharbel SouaidHimanshu SinghLan T. M. DaoSaadat HussainAlejandra Medina-RiveraLucia Ramirez-NavarroJaime A. Castro-MondragonNori SadouniGuillaume CharbonnierSalvatore SpicugliaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Santiago-Algarra Charbel Souaid Himanshu Singh Lan T. M. Dao Saadat Hussain Alejandra Medina-Rivera Lucia Ramirez-Navarro Jaime A. Castro-Mondragon Nori Sadouni Guillaume Charbonnier Salvatore Spicuglia Epromoters function as a hub to recruit key transcription factors required for the inflammatory response
description	Some promoters, termed Epromoters, can display enhancer activity and regulate distal genes in their endogenous context. Here the authors report the broad involvement of Epromoters in the coordinated activation of interferon (IFN) response. They show activation of a number of IFN-inducible genes is a result of Epromoters regulating expression of an entire IFN response gene cluster.
format	article
author	David Santiago-Algarra Charbel Souaid Himanshu Singh Lan T. M. Dao Saadat Hussain Alejandra Medina-Rivera Lucia Ramirez-Navarro Jaime A. Castro-Mondragon Nori Sadouni Guillaume Charbonnier Salvatore Spicuglia
author_facet	David Santiago-Algarra Charbel Souaid Himanshu Singh Lan T. M. Dao Saadat Hussain Alejandra Medina-Rivera Lucia Ramirez-Navarro Jaime A. Castro-Mondragon Nori Sadouni Guillaume Charbonnier Salvatore Spicuglia
author_sort	David Santiago-Algarra
title	Epromoters function as a hub to recruit key transcription factors required for the inflammatory response
title_short	Epromoters function as a hub to recruit key transcription factors required for the inflammatory response
title_full	Epromoters function as a hub to recruit key transcription factors required for the inflammatory response
title_fullStr	Epromoters function as a hub to recruit key transcription factors required for the inflammatory response
title_full_unstemmed	Epromoters function as a hub to recruit key transcription factors required for the inflammatory response
title_sort	epromoters function as a hub to recruit key transcription factors required for the inflammatory response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a838a6dac1c4a42aac0c04facbcf0f8
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Epromoters function as a hub to recruit key transcription factors required for the inflammatory response

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