DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

DNA methylation is one of the major epigenetic mechanisms that critically influence gene expression, genomic stability and cell differentiation. Here, the authors study DNMT1 in complex with DNA substrates and systematically analyze the mechanism and specificity of DNMT1.

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Autores principales: Sabrina Adam, Hiwot Anteneh, Maximilian Hornisch, Vincent Wagner, Jiuwei Lu, Nicole E. Radde, Pavel Bashtrykov, Jikui Song, Albert Jeltsch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/2a8467615fb941e58c2a50d0f3dac5b8
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spelling oai:doaj.org-article:2a8467615fb941e58c2a50d0f3dac5b82021-12-02T16:26:32ZDNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation10.1038/s41467-020-17531-82041-1723https://doaj.org/article/2a8467615fb941e58c2a50d0f3dac5b82020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17531-8https://doaj.org/toc/2041-1723DNA methylation is one of the major epigenetic mechanisms that critically influence gene expression, genomic stability and cell differentiation. Here, the authors study DNMT1 in complex with DNA substrates and systematically analyze the mechanism and specificity of DNMT1.Sabrina AdamHiwot AntenehMaximilian HornischVincent WagnerJiuwei LuNicole E. RaddePavel BashtrykovJikui SongAlbert JeltschNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sabrina Adam
Hiwot Anteneh
Maximilian Hornisch
Vincent Wagner
Jiuwei Lu
Nicole E. Radde
Pavel Bashtrykov
Jikui Song
Albert Jeltsch
DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
description DNA methylation is one of the major epigenetic mechanisms that critically influence gene expression, genomic stability and cell differentiation. Here, the authors study DNMT1 in complex with DNA substrates and systematically analyze the mechanism and specificity of DNMT1.
format article
author Sabrina Adam
Hiwot Anteneh
Maximilian Hornisch
Vincent Wagner
Jiuwei Lu
Nicole E. Radde
Pavel Bashtrykov
Jikui Song
Albert Jeltsch
author_facet Sabrina Adam
Hiwot Anteneh
Maximilian Hornisch
Vincent Wagner
Jiuwei Lu
Nicole E. Radde
Pavel Bashtrykov
Jikui Song
Albert Jeltsch
author_sort Sabrina Adam
title DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
title_short DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
title_full DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
title_fullStr DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
title_full_unstemmed DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
title_sort dna sequence-dependent activity and base flipping mechanisms of dnmt1 regulate genome-wide dna methylation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2a8467615fb941e58c2a50d0f3dac5b8
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