Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients

Abstract Many Parkinson’s disease (PD) patients notice that motor symptoms worsen during stress, and experience stress-related neuropsychiatric symptoms such as anxiety and depression. Here we investigated which personal and disease characteristics are associated with perceived stress in PD, which P...

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Autores principales:	Anouk van der Heide, Anne E. M. Speckens, Marjan J. Meinders, Liana S. Rosenthal, Bastiaan R. Bloem, Rick C. Helmich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2a8796853287428cbed536b8e3654354
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spelling	oai:doaj.org-article:2a8796853287428cbed536b8e36543542021-12-02T10:55:20ZStress and mindfulness in Parkinson’s disease – a survey in 5000 patients10.1038/s41531-020-00152-92373-8057https://doaj.org/article/2a8796853287428cbed536b8e36543542021-01-01T00:00:00Zhttps://doi.org/10.1038/s41531-020-00152-9https://doaj.org/toc/2373-8057Abstract Many Parkinson’s disease (PD) patients notice that motor symptoms worsen during stress, and experience stress-related neuropsychiatric symptoms such as anxiety and depression. Here we investigated which personal and disease characteristics are associated with perceived stress in PD, which PD symptoms are sensitive to stress, and we assessed self-reported benefits of stress-reducing strategies such as mindfulness. We sent an online survey to the Fox Insight cohort (n = 28,385 PD patients, n = 11,413 healthy controls). The survey included specific questions about the influence of stress on PD symptoms, use of stress-reducing strategies, and several validated scales measuring perceived stress, anxiety, dispositional mindfulness, rumination, and self-compassion. We received completed surveys from 5000 PD patients and 1292 controls. Patients perceived more stress than controls. Among patients, stress was correlated with increased rumination (R = 0.65), lower quality of life (R = −0.56), lower self-compassion (R = −0.65), and lower dispositional mindfulness (R = −0.48). Furthermore, patients indicated that stress significantly worsened both motor symptoms – especially tremor – and non-motor symptoms. Physical exercise was most frequently used to reduce stress (83.1%). Mindfulness was practiced by 38.7% of PD respondents, who noticed improvement in both motor and non-motor symptoms. Among non-users, 43.4% were interested in gaining mindfulness skills. We conclude that PD patients experience greater levels of stress than controls, and that stress worsens both motor and non-motor symptoms. Mindfulness may improve PD symptom severity, with the strongest effects on anxiety and depressed mood. These findings justify further controlled studies to establish the merits of mindfulness and other stress-alleviating interventions.Anouk van der HeideAnne E. M. SpeckensMarjan J. MeindersLiana S. RosenthalBastiaan R. BloemRick C. HelmichNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Anouk van der Heide Anne E. M. Speckens Marjan J. Meinders Liana S. Rosenthal Bastiaan R. Bloem Rick C. Helmich Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients
description	Abstract Many Parkinson’s disease (PD) patients notice that motor symptoms worsen during stress, and experience stress-related neuropsychiatric symptoms such as anxiety and depression. Here we investigated which personal and disease characteristics are associated with perceived stress in PD, which PD symptoms are sensitive to stress, and we assessed self-reported benefits of stress-reducing strategies such as mindfulness. We sent an online survey to the Fox Insight cohort (n = 28,385 PD patients, n = 11,413 healthy controls). The survey included specific questions about the influence of stress on PD symptoms, use of stress-reducing strategies, and several validated scales measuring perceived stress, anxiety, dispositional mindfulness, rumination, and self-compassion. We received completed surveys from 5000 PD patients and 1292 controls. Patients perceived more stress than controls. Among patients, stress was correlated with increased rumination (R = 0.65), lower quality of life (R = −0.56), lower self-compassion (R = −0.65), and lower dispositional mindfulness (R = −0.48). Furthermore, patients indicated that stress significantly worsened both motor symptoms – especially tremor – and non-motor symptoms. Physical exercise was most frequently used to reduce stress (83.1%). Mindfulness was practiced by 38.7% of PD respondents, who noticed improvement in both motor and non-motor symptoms. Among non-users, 43.4% were interested in gaining mindfulness skills. We conclude that PD patients experience greater levels of stress than controls, and that stress worsens both motor and non-motor symptoms. Mindfulness may improve PD symptom severity, with the strongest effects on anxiety and depressed mood. These findings justify further controlled studies to establish the merits of mindfulness and other stress-alleviating interventions.
format	article
author	Anouk van der Heide Anne E. M. Speckens Marjan J. Meinders Liana S. Rosenthal Bastiaan R. Bloem Rick C. Helmich
author_facet	Anouk van der Heide Anne E. M. Speckens Marjan J. Meinders Liana S. Rosenthal Bastiaan R. Bloem Rick C. Helmich
author_sort	Anouk van der Heide
title	Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients
title_short	Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients
title_full	Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients
title_fullStr	Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients
title_full_unstemmed	Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients
title_sort	stress and mindfulness in parkinson’s disease – a survey in 5000 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a8796853287428cbed536b8e3654354
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Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients

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