Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes

Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between pro...

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Autores principales:	Alicja Popiołek, Bartosz Brzoszczyk, Piotr Jarzemski, Aleksandra Chyrek-Tomaszewska, Radosław Wieczór, Alina Borkowska, Maciej Bieliński
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate cancer cognitive function cancer-related cognitive impairment biomarkers prostate-specific antigen testosterone Medicine R
Acceso en línea:	https://doaj.org/article/2a8b495da5914814a5f67a9304485dd9
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spelling	oai:doaj.org-article:2a8b495da5914814a5f67a9304485dd92021-11-25T18:01:36ZProstate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes10.3390/jcm102253072077-0383https://doaj.org/article/2a8b495da5914814a5f67a9304485dd92021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5307https://doaj.org/toc/2077-0383Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between prostate-specific antigen (PSA) or testosterone (T) levels and cognitive function in patients undergoing radical prostatectomy. Such a correlation could help identify patient groups at risk of cognitive impairment. Participants underwent clinical (demographic data, medical history, physical examination, and blood analyses) and neuropsychological assessment (cognitive test battery). Preoperative PSA or T levels were not associated with cognitive function. However, long-term follow-up after prostatectomy showed a strong correlation between PSA levels and the results of verbal memory and executive function tests. A trend toward significance was also observed for visuospatial memory. The levels of free T and total T were not correlated with cognitive function. Only the levels of free T after hormonal treatment were significantly correlated with executive functions. Comorbid diabetes affected these correlations. In conclusion, PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function.Alicja PopiołekBartosz BrzoszczykPiotr JarzemskiAleksandra Chyrek-TomaszewskaRadosław WieczórAlina BorkowskaMaciej BielińskiMDPI AGarticleprostate cancercognitive functioncancer-related cognitive impairmentbiomarkersprostate-specific antigentestosteroneMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5307, p 5307 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer cognitive function cancer-related cognitive impairment biomarkers prostate-specific antigen testosterone Medicine R
spellingShingle	prostate cancer cognitive function cancer-related cognitive impairment biomarkers prostate-specific antigen testosterone Medicine R Alicja Popiołek Bartosz Brzoszczyk Piotr Jarzemski Aleksandra Chyrek-Tomaszewska Radosław Wieczór Alina Borkowska Maciej Bieliński Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes
description	Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between prostate-specific antigen (PSA) or testosterone (T) levels and cognitive function in patients undergoing radical prostatectomy. Such a correlation could help identify patient groups at risk of cognitive impairment. Participants underwent clinical (demographic data, medical history, physical examination, and blood analyses) and neuropsychological assessment (cognitive test battery). Preoperative PSA or T levels were not associated with cognitive function. However, long-term follow-up after prostatectomy showed a strong correlation between PSA levels and the results of verbal memory and executive function tests. A trend toward significance was also observed for visuospatial memory. The levels of free T and total T were not correlated with cognitive function. Only the levels of free T after hormonal treatment were significantly correlated with executive functions. Comorbid diabetes affected these correlations. In conclusion, PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function.
format	article
author	Alicja Popiołek Bartosz Brzoszczyk Piotr Jarzemski Aleksandra Chyrek-Tomaszewska Radosław Wieczór Alina Borkowska Maciej Bieliński
author_facet	Alicja Popiołek Bartosz Brzoszczyk Piotr Jarzemski Aleksandra Chyrek-Tomaszewska Radosław Wieczór Alina Borkowska Maciej Bieliński
author_sort	Alicja Popiołek
title	Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes
title_short	Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes
title_full	Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes
title_fullStr	Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes
title_full_unstemmed	Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes
title_sort	prostate-specific antigen and testosterone levels as biochemical indicators of cognitive function in prostate cancer survivors and the role of diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2a8b495da5914814a5f67a9304485dd9
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Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes

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