Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer

ABSTRACT White-tailed deer (Odocoileus virginianus), an ecologically and economically important species, are the most widely distributed large animals in North America. A recent study indicated that up to 25% of all white-tailed deer may be infected with Plasmodium odocoilei, a malaria parasite belo...

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Autores principales:	Ann M. Guggisberg, Katherine A. Sayler, Samantha M. Wisely, Audrey R. Odom John
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	malaria Odocoilei virginianus Plasmodium Plasmodium odocoilei veterinary parasitology white-tailed deer Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2a8bc1e043b241b2847fcf13080e814b
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spelling	oai:doaj.org-article:2a8bc1e043b241b2847fcf13080e814b2021-11-15T15:22:13ZNatural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer10.1128/mSphere.00067-182379-5042https://doaj.org/article/2a8bc1e043b241b2847fcf13080e814b2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00067-18https://doaj.org/toc/2379-5042ABSTRACT White-tailed deer (Odocoileus virginianus), an ecologically and economically important species, are the most widely distributed large animals in North America. A recent study indicated that up to 25% of all white-tailed deer may be infected with Plasmodium odocoilei, a malaria parasite belonging to the distinct clade of ungulate-infecting Plasmodium spp. Because the clinical impact of P. odocoilei on deer health and survival is unknown, we undertook a retrospective longitudinal study of farmed Floridian O. virginianus fawns. We found that a substantial proportion (21%) of fawns acquire malaria infection during the first 8 months of life. Some animals naturally clear P. odocoilei infection, while other animals remain persistently positive. Importantly, we found that animals that acquire malaria parasites very early in life have poor survival compared to animals that remain uninfected. Our report thus provides the first evidence of a clinically significant impact of malaria infection in young deer. IMPORTANCE Malaria parasites of the genus Plasmodium are known to infect a variety of vertebrate hosts, including ungulates (hoofed mammals). A recent study found that up to a quarter of white-tailed deer (Odocoileus virginianus) in North America are infected with the parasite Plasmodium odocoilei. In addition to occupying an important ecological niche, white-tailed deer are popular game animals and deer farming represents a rapidly growing industry. However, the effect of P. odocoilei infection in this ecologically and economically important ungulate species is unknown. Our work is significant because (i) we identified a high prevalence of P. odocoilei in farmed deer and (ii) we found evidence for both cleared and persistent infection, as well as an association with decreased survival of young fawns.Ann M. GuggisbergKatherine A. SaylerSamantha M. WiselyAudrey R. Odom JohnAmerican Society for MicrobiologyarticlemalariaOdocoilei virginianusPlasmodiumPlasmodium odocoileiveterinary parasitologywhite-tailed deerMicrobiologyQR1-502ENmSphere, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	malaria Odocoilei virginianus Plasmodium Plasmodium odocoilei veterinary parasitology white-tailed deer Microbiology QR1-502
spellingShingle	malaria Odocoilei virginianus Plasmodium Plasmodium odocoilei veterinary parasitology white-tailed deer Microbiology QR1-502 Ann M. Guggisberg Katherine A. Sayler Samantha M. Wisely Audrey R. Odom John Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer
description	ABSTRACT White-tailed deer (Odocoileus virginianus), an ecologically and economically important species, are the most widely distributed large animals in North America. A recent study indicated that up to 25% of all white-tailed deer may be infected with Plasmodium odocoilei, a malaria parasite belonging to the distinct clade of ungulate-infecting Plasmodium spp. Because the clinical impact of P. odocoilei on deer health and survival is unknown, we undertook a retrospective longitudinal study of farmed Floridian O. virginianus fawns. We found that a substantial proportion (21%) of fawns acquire malaria infection during the first 8 months of life. Some animals naturally clear P. odocoilei infection, while other animals remain persistently positive. Importantly, we found that animals that acquire malaria parasites very early in life have poor survival compared to animals that remain uninfected. Our report thus provides the first evidence of a clinically significant impact of malaria infection in young deer. IMPORTANCE Malaria parasites of the genus Plasmodium are known to infect a variety of vertebrate hosts, including ungulates (hoofed mammals). A recent study found that up to a quarter of white-tailed deer (Odocoileus virginianus) in North America are infected with the parasite Plasmodium odocoilei. In addition to occupying an important ecological niche, white-tailed deer are popular game animals and deer farming represents a rapidly growing industry. However, the effect of P. odocoilei infection in this ecologically and economically important ungulate species is unknown. Our work is significant because (i) we identified a high prevalence of P. odocoilei in farmed deer and (ii) we found evidence for both cleared and persistent infection, as well as an association with decreased survival of young fawns.
format	article
author	Ann M. Guggisberg Katherine A. Sayler Samantha M. Wisely Audrey R. Odom John
author_facet	Ann M. Guggisberg Katherine A. Sayler Samantha M. Wisely Audrey R. Odom John
author_sort	Ann M. Guggisberg
title	Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer
title_short	Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer
title_full	Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer
title_fullStr	Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer
title_full_unstemmed	Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer
title_sort	natural history of <italic toggle="yes">plasmodium odocoilei</italic> malaria infection in farmed white-tailed deer
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/2a8bc1e043b241b2847fcf13080e814b
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Natural History of <italic toggle="yes">Plasmodium odocoilei</italic> Malaria Infection in Farmed White-Tailed Deer

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