Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?

A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitoc...

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Autores principales:	Emily Wood, Katherine H. Hall, Warren Tate
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2a8c1d4d6bfb4492997ea025186013f3
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spelling	oai:doaj.org-article:2a8c1d4d6bfb4492997ea025186013f32021-12-02T11:38:30ZRole of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?2095-882X10.1016/j.cdtm.2020.11.002https://doaj.org/article/2a8c1d4d6bfb4492997ea025186013f32021-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X20300839https://doaj.org/toc/2095-882XA significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue. It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. This study identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches.Emily WoodKatherine H. HallWarren TateKeAi Communications Co., Ltd.articleChronic fatigue syndromeMitochondriaOxidative stressAntioxidantsSARS-CoV-2Medicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 7, Iss 1, Pp 14-26 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2 Medicine (General) R5-920
spellingShingle	Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2 Medicine (General) R5-920 Emily Wood Katherine H. Hall Warren Tate Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
description	A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue. It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. This study identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches.
format	article
author	Emily Wood Katherine H. Hall Warren Tate
author_facet	Emily Wood Katherine H. Hall Warren Tate
author_sort	Emily Wood
title	Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
title_short	Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
title_full	Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
title_fullStr	Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
title_full_unstemmed	Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
title_sort	role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: a possible approach to sars-cov-2 ‘long-haulers’?
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/2a8c1d4d6bfb4492997ea025186013f3
work_keys_str_mv	AT emilywood roleofmitochondriaoxidativestressandtheresponsetoantioxidantsinmyalgicencephalomyelitischronicfatiguesyndromeapossibleapproachtosarscov2longhaulers AT katherinehhall roleofmitochondriaoxidativestressandtheresponsetoantioxidantsinmyalgicencephalomyelitischronicfatiguesyndromeapossibleapproachtosarscov2longhaulers AT warrentate roleofmitochondriaoxidativestressandtheresponsetoantioxidantsinmyalgicencephalomyelitischronicfatiguesyndromeapossibleapproachtosarscov2longhaulers
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Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?

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