Near-Cognate Codons Contribute Complexity to Translation Regulation

ABSTRACT The interplay between translation initiation, modification of translation initiation factors, and selection of start sites on mRNA for protein synthesis can play a regulatory role in the cellular response to stress, development, and cell fate in eukaryotic species by shaping the proteome. A...

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Autor principal:	N. Louise Glass
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	cross-pathway control near-cognate codons translation uORFs Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2a8c636723264797903112fd67728810
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spelling	oai:doaj.org-article:2a8c636723264797903112fd677288102021-11-15T15:51:56ZNear-Cognate Codons Contribute Complexity to Translation Regulation10.1128/mBio.01820-172150-7511https://doaj.org/article/2a8c636723264797903112fd677288102017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01820-17https://doaj.org/toc/2150-7511ABSTRACT The interplay between translation initiation, modification of translation initiation factors, and selection of start sites on mRNA for protein synthesis can play a regulatory role in the cellular response to stress, development, and cell fate in eukaryotic species by shaping the proteome. As shown by Ivanov et al. (mBio 8:e00844-17, 2017, https://doi.org/10.1128/mBio.00844-17 ), in the filamentous fungus Neurospora crassa, both upstream open reading frames (uORFs) and near-cognate start codons negatively or positively regulate the translation of the transcription factor CPC1 and production of CPC1 isoforms, which mediate the cellular response to amino acid starvation. Dissecting the physiological roles that differentiate cellular choice of translation initiation is an important parameter to understanding mechanisms that determine cell fate via gene regulation and protein synthesis.N. Louise GlassAmerican Society for Microbiologyarticlecross-pathway controlnear-cognate codonstranslationuORFsMicrobiologyQR1-502ENmBio, Vol 8, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	cross-pathway control near-cognate codons translation uORFs Microbiology QR1-502
spellingShingle	cross-pathway control near-cognate codons translation uORFs Microbiology QR1-502 N. Louise Glass Near-Cognate Codons Contribute Complexity to Translation Regulation
description	ABSTRACT The interplay between translation initiation, modification of translation initiation factors, and selection of start sites on mRNA for protein synthesis can play a regulatory role in the cellular response to stress, development, and cell fate in eukaryotic species by shaping the proteome. As shown by Ivanov et al. (mBio 8:e00844-17, 2017, https://doi.org/10.1128/mBio.00844-17 ), in the filamentous fungus Neurospora crassa, both upstream open reading frames (uORFs) and near-cognate start codons negatively or positively regulate the translation of the transcription factor CPC1 and production of CPC1 isoforms, which mediate the cellular response to amino acid starvation. Dissecting the physiological roles that differentiate cellular choice of translation initiation is an important parameter to understanding mechanisms that determine cell fate via gene regulation and protein synthesis.
format	article
author	N. Louise Glass
author_facet	N. Louise Glass
author_sort	N. Louise Glass
title	Near-Cognate Codons Contribute Complexity to Translation Regulation
title_short	Near-Cognate Codons Contribute Complexity to Translation Regulation
title_full	Near-Cognate Codons Contribute Complexity to Translation Regulation
title_fullStr	Near-Cognate Codons Contribute Complexity to Translation Regulation
title_full_unstemmed	Near-Cognate Codons Contribute Complexity to Translation Regulation
title_sort	near-cognate codons contribute complexity to translation regulation
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/2a8c636723264797903112fd67728810
work_keys_str_mv	AT nlouiseglass nearcognatecodonscontributecomplexitytotranslationregulation
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Near-Cognate Codons Contribute Complexity to Translation Regulation

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