Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia

Abstract The impact of different types of reactive case detection and/or treatment strategies for malaria elimination depends on high coverage and participants’ adherence. However, strategies to optimise adherence are limited, particularly for people with asymptomatic or no infections. As part of a...

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Autores principales:	Fatou Jaiteh, Joseph Okebe, Yoriko Masunaga, Umberto D’Alessandro, Jane Achan, Charlotte Gryseels, Daniel de Vries, Joan Muela Ribera, Koen Peeters Grietens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a8f59502b034e1a8552aa0f3c15ce13
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spelling	oai:doaj.org-article:2a8f59502b034e1a8552aa0f3c15ce132021-12-02T14:09:01ZUnderstanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia10.1038/s41598-021-81468-12045-2322https://doaj.org/article/2a8f59502b034e1a8552aa0f3c15ce132021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81468-1https://doaj.org/toc/2045-2322Abstract The impact of different types of reactive case detection and/or treatment strategies for malaria elimination depends on high coverage and participants’ adherence. However, strategies to optimise adherence are limited, particularly for people with asymptomatic or no infections. As part of a cluster-randomized trial to evaluate the effect of reactive treatment in The Gambia, all residents in the compound of a diagnosed clinical malaria patient received dihydro-artemisinin–piperaquine (DP). Using a mixed method approach, we assessed which factors contribute to adherence among the contacts of malaria cases that showed no symptoms. Adherence was defined as the proportion of compound members that (1) returned all medicine bags empty and (2) self-reported (3-day) treatment completion. Among the 273 individuals from 14 compounds who received DP, 227 (83.1%) were available for and willing to participate in the survey; 85.3% (233/273) returned empty medicine bags and 91.6% (208/227) self-reported treatment completion. Although clinical malaria was not considered a major health problem, reported adherence was high. The drivers of adherence were the strong sense of responsibility towards protecting the individual, compound and the village. Adherence can be optimised through a transdisciplinary implementation research process of engaging communities to bridge the gap between research goals and social realities.Fatou JaitehJoseph OkebeYoriko MasunagaUmberto D’AlessandroJane AchanCharlotte GryseelsDaniel de VriesJoan Muela RiberaKoen Peeters GrietensNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fatou Jaiteh Joseph Okebe Yoriko Masunaga Umberto D’Alessandro Jane Achan Charlotte Gryseels Daniel de Vries Joan Muela Ribera Koen Peeters Grietens Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia
description	Abstract The impact of different types of reactive case detection and/or treatment strategies for malaria elimination depends on high coverage and participants’ adherence. However, strategies to optimise adherence are limited, particularly for people with asymptomatic or no infections. As part of a cluster-randomized trial to evaluate the effect of reactive treatment in The Gambia, all residents in the compound of a diagnosed clinical malaria patient received dihydro-artemisinin–piperaquine (DP). Using a mixed method approach, we assessed which factors contribute to adherence among the contacts of malaria cases that showed no symptoms. Adherence was defined as the proportion of compound members that (1) returned all medicine bags empty and (2) self-reported (3-day) treatment completion. Among the 273 individuals from 14 compounds who received DP, 227 (83.1%) were available for and willing to participate in the survey; 85.3% (233/273) returned empty medicine bags and 91.6% (208/227) self-reported treatment completion. Although clinical malaria was not considered a major health problem, reported adherence was high. The drivers of adherence were the strong sense of responsibility towards protecting the individual, compound and the village. Adherence can be optimised through a transdisciplinary implementation research process of engaging communities to bridge the gap between research goals and social realities.
format	article
author	Fatou Jaiteh Joseph Okebe Yoriko Masunaga Umberto D’Alessandro Jane Achan Charlotte Gryseels Daniel de Vries Joan Muela Ribera Koen Peeters Grietens
author_facet	Fatou Jaiteh Joseph Okebe Yoriko Masunaga Umberto D’Alessandro Jane Achan Charlotte Gryseels Daniel de Vries Joan Muela Ribera Koen Peeters Grietens
author_sort	Fatou Jaiteh
title	Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia
title_short	Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia
title_full	Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia
title_fullStr	Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia
title_full_unstemmed	Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia
title_sort	understanding adherence to reactive treatment of asymptomatic malaria infections in the gambia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a8f59502b034e1a8552aa0f3c15ce13
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Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia

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