Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

Brain metastases are a major reason for lung cancer mortality. Here, the authors modify lonidamine to target mitochondria, and show its therapeutic efficacy in inhibiting lung cancer brain metastasis by inducing autophagic cell death in cancer cells.

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Autores principales:	Gang Cheng, Qi Zhang, Jing Pan, Yongik Lee, Olivier Ouari, Micael Hardy, Monika Zielonka, Charles R. Myers, Jacek Zielonka, Katherine Weh, Andrew C. Chang, Guoan Chen, Laura Kresty, Balaraman Kalyanaraman, Ming You
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a91f216e7964b0b95ec04c9938932cc
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spelling	oai:doaj.org-article:2a91f216e7964b0b95ec04c9938932cc2021-12-02T14:40:18ZTargeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis10.1038/s41467-019-10042-12041-1723https://doaj.org/article/2a91f216e7964b0b95ec04c9938932cc2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10042-1https://doaj.org/toc/2041-1723Brain metastases are a major reason for lung cancer mortality. Here, the authors modify lonidamine to target mitochondria, and show its therapeutic efficacy in inhibiting lung cancer brain metastasis by inducing autophagic cell death in cancer cells.Gang ChengQi ZhangJing PanYongik LeeOlivier OuariMicael HardyMonika ZielonkaCharles R. MyersJacek ZielonkaKatherine WehAndrew C. ChangGuoan ChenLaura KrestyBalaraman KalyanaramanMing YouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Cheng Qi Zhang Jing Pan Yongik Lee Olivier Ouari Micael Hardy Monika Zielonka Charles R. Myers Jacek Zielonka Katherine Weh Andrew C. Chang Guoan Chen Laura Kresty Balaraman Kalyanaraman Ming You Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
description	Brain metastases are a major reason for lung cancer mortality. Here, the authors modify lonidamine to target mitochondria, and show its therapeutic efficacy in inhibiting lung cancer brain metastasis by inducing autophagic cell death in cancer cells.
format	article
author	Gang Cheng Qi Zhang Jing Pan Yongik Lee Olivier Ouari Micael Hardy Monika Zielonka Charles R. Myers Jacek Zielonka Katherine Weh Andrew C. Chang Guoan Chen Laura Kresty Balaraman Kalyanaraman Ming You
author_facet	Gang Cheng Qi Zhang Jing Pan Yongik Lee Olivier Ouari Micael Hardy Monika Zielonka Charles R. Myers Jacek Zielonka Katherine Weh Andrew C. Chang Guoan Chen Laura Kresty Balaraman Kalyanaraman Ming You
author_sort	Gang Cheng
title	Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
title_short	Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
title_full	Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
title_fullStr	Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
title_full_unstemmed	Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
title_sort	targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2a91f216e7964b0b95ec04c9938932cc
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Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

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