Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)

Abstract To assess the quality of life of keratoconus patients using the Keratoconus Outcomes Research Questionnaire (KORQ), translated and validated in Portuguese language. The KORQ is the only validated keratoconus specific questionnaire and has a high rating for its psychometric properties. This...

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Autores principales:	Roberto Damian Pacheco Pinto, Ricardo Yuji Abe, Flávia Cid Gomes, Paulo Rodolfo Tagliari Barbisan, Alexandre Fattah Martini, Daniel de Almeida Borges, Arthur Gustavo Fernandes, Carlos Eduardo Leite Arieta, Monica Alves
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a9441c051624195ac5407543dbdf729
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spelling	oai:doaj.org-article:2a9441c051624195ac5407543dbdf7292021-12-02T17:45:20ZQuality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)10.1038/s41598-021-92346-12045-2322https://doaj.org/article/2a9441c051624195ac5407543dbdf7292021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92346-1https://doaj.org/toc/2045-2322Abstract To assess the quality of life of keratoconus patients using the Keratoconus Outcomes Research Questionnaire (KORQ), translated and validated in Portuguese language. The KORQ is the only validated keratoconus specific questionnaire and has a high rating for its psychometric properties. This cross-sectional study enrolled 100 keratoconus patients from a tertiary referral eye hospital between April 2018 and June 2019. Associations between age, sex, allergic conjunctivitis, keratoconus stage, best-corrected visual acuity (BCVA), maximum simulated keratometry (Kmax), steep keratometry (K2), pachymetry, treatments performed, hydrops, and KORQ scores were evaluated using univariate (Wilcoxon test and the Kruskal Wallis test) and multivariate linear regression with stepwise backward modeling. Lower KORQ scores are associated with better quality of life, whereas, higher scores are associated with greater impairment of functional activities and symptoms. Among the 100 patients, mild, moderate, and severe keratoconus were observed in 15%, 46% and 39% of participants, respectively. Univariate analysis showed lower function scores values, with male sex (p < 0.05) and both functional and symptom scores were significantly associated with BCVA < 0.3 (LogMAR) (p < 0.05). Multivariate analysis indicated significantly lower functional scores in individuals with BCVA < 0.3 (LogMAR) (p < 0.001) and those with a history of crosslinking treatment (p = 0.022), while symptom scores were only significantly associated with only BCVA < 0.3 (LogMAR) (p < 0.001). In patients with keratoconus, BCVA in the better eye and history of crosslinkig were factors associated with better quality of life scores using the KORQ.Roberto Damian Pacheco PintoRicardo Yuji AbeFlávia Cid GomesPaulo Rodolfo Tagliari BarbisanAlexandre Fattah MartiniDaniel de Almeida BorgesArthur Gustavo FernandesCarlos Eduardo Leite ArietaMonica AlvesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roberto Damian Pacheco Pinto Ricardo Yuji Abe Flávia Cid Gomes Paulo Rodolfo Tagliari Barbisan Alexandre Fattah Martini Daniel de Almeida Borges Arthur Gustavo Fernandes Carlos Eduardo Leite Arieta Monica Alves Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)
description	Abstract To assess the quality of life of keratoconus patients using the Keratoconus Outcomes Research Questionnaire (KORQ), translated and validated in Portuguese language. The KORQ is the only validated keratoconus specific questionnaire and has a high rating for its psychometric properties. This cross-sectional study enrolled 100 keratoconus patients from a tertiary referral eye hospital between April 2018 and June 2019. Associations between age, sex, allergic conjunctivitis, keratoconus stage, best-corrected visual acuity (BCVA), maximum simulated keratometry (Kmax), steep keratometry (K2), pachymetry, treatments performed, hydrops, and KORQ scores were evaluated using univariate (Wilcoxon test and the Kruskal Wallis test) and multivariate linear regression with stepwise backward modeling. Lower KORQ scores are associated with better quality of life, whereas, higher scores are associated with greater impairment of functional activities and symptoms. Among the 100 patients, mild, moderate, and severe keratoconus were observed in 15%, 46% and 39% of participants, respectively. Univariate analysis showed lower function scores values, with male sex (p < 0.05) and both functional and symptom scores were significantly associated with BCVA < 0.3 (LogMAR) (p < 0.05). Multivariate analysis indicated significantly lower functional scores in individuals with BCVA < 0.3 (LogMAR) (p < 0.001) and those with a history of crosslinking treatment (p = 0.022), while symptom scores were only significantly associated with only BCVA < 0.3 (LogMAR) (p < 0.001). In patients with keratoconus, BCVA in the better eye and history of crosslinkig were factors associated with better quality of life scores using the KORQ.
format	article
author	Roberto Damian Pacheco Pinto Ricardo Yuji Abe Flávia Cid Gomes Paulo Rodolfo Tagliari Barbisan Alexandre Fattah Martini Daniel de Almeida Borges Arthur Gustavo Fernandes Carlos Eduardo Leite Arieta Monica Alves
author_facet	Roberto Damian Pacheco Pinto Ricardo Yuji Abe Flávia Cid Gomes Paulo Rodolfo Tagliari Barbisan Alexandre Fattah Martini Daniel de Almeida Borges Arthur Gustavo Fernandes Carlos Eduardo Leite Arieta Monica Alves
author_sort	Roberto Damian Pacheco Pinto
title	Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)
title_short	Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)
title_full	Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)
title_fullStr	Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)
title_full_unstemmed	Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)
title_sort	quality of life in keratoconus: evaluation with keratoconus outcomes research questionnaire (korq)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a9441c051624195ac5407543dbdf729
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Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ)

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