Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

Extracellular vesicles (EVs) play a role in intercellular communication, however the precise biogenesis of different populations of EVs are not clear. Here, the authors follow the intracellular trafficking of two proteins before their secretion in EVs and report the biogenesis and protein markers of...

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Autores principales: Mathilde Mathieu, Nathalie Névo, Mabel Jouve, José Ignacio Valenzuela, Mathieu Maurin, Frederik J. Verweij, Roberta Palmulli, Danielle Lankar, Florent Dingli, Damarys Loew, Eric Rubinstein, Gaëlle Boncompain, Franck Perez, Clotilde Théry
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2a99280c1b6f41468059cf3f612d221d
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spelling oai:doaj.org-article:2a99280c1b6f41468059cf3f612d221d2021-12-02T17:57:16ZSpecificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD910.1038/s41467-021-24384-22041-1723https://doaj.org/article/2a99280c1b6f41468059cf3f612d221d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24384-2https://doaj.org/toc/2041-1723Extracellular vesicles (EVs) play a role in intercellular communication, however the precise biogenesis of different populations of EVs are not clear. Here, the authors follow the intracellular trafficking of two proteins before their secretion in EVs and report the biogenesis and protein markers of EV subtypes: ectosomes budding from the plasma membrane as well as exosomes from late endosomes.Mathilde MathieuNathalie NévoMabel JouveJosé Ignacio ValenzuelaMathieu MaurinFrederik J. VerweijRoberta PalmulliDanielle LankarFlorent DingliDamarys LoewEric RubinsteinGaëlle BoncompainFranck PerezClotilde ThéryNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mathilde Mathieu
Nathalie Névo
Mabel Jouve
José Ignacio Valenzuela
Mathieu Maurin
Frederik J. Verweij
Roberta Palmulli
Danielle Lankar
Florent Dingli
Damarys Loew
Eric Rubinstein
Gaëlle Boncompain
Franck Perez
Clotilde Théry
Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
description Extracellular vesicles (EVs) play a role in intercellular communication, however the precise biogenesis of different populations of EVs are not clear. Here, the authors follow the intracellular trafficking of two proteins before their secretion in EVs and report the biogenesis and protein markers of EV subtypes: ectosomes budding from the plasma membrane as well as exosomes from late endosomes.
format article
author Mathilde Mathieu
Nathalie Névo
Mabel Jouve
José Ignacio Valenzuela
Mathieu Maurin
Frederik J. Verweij
Roberta Palmulli
Danielle Lankar
Florent Dingli
Damarys Loew
Eric Rubinstein
Gaëlle Boncompain
Franck Perez
Clotilde Théry
author_facet Mathilde Mathieu
Nathalie Névo
Mabel Jouve
José Ignacio Valenzuela
Mathieu Maurin
Frederik J. Verweij
Roberta Palmulli
Danielle Lankar
Florent Dingli
Damarys Loew
Eric Rubinstein
Gaëlle Boncompain
Franck Perez
Clotilde Théry
author_sort Mathilde Mathieu
title Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
title_short Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
title_full Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
title_fullStr Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
title_full_unstemmed Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
title_sort specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of cd63 and cd9
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2a99280c1b6f41468059cf3f612d221d
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