Single-cell transcriptome analysis of the zebrafish embryonic trunk.

During embryonic development, cells differentiate into a variety of distinct cell types and subtypes with diverse transcriptional profiles. To date, transcriptomic signatures of different cell lineages that arise during development have been only partially characterized. Here we used single-cell RNA...

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Autores principales:	Sanjeeva Metikala, Satish Casie Chetty, Saulius Sumanas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a993f33fbd341a3abfadcc10ba07687
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spelling	oai:doaj.org-article:2a993f33fbd341a3abfadcc10ba076872021-12-02T20:09:38ZSingle-cell transcriptome analysis of the zebrafish embryonic trunk.1932-620310.1371/journal.pone.0254024https://doaj.org/article/2a993f33fbd341a3abfadcc10ba076872021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254024https://doaj.org/toc/1932-6203During embryonic development, cells differentiate into a variety of distinct cell types and subtypes with diverse transcriptional profiles. To date, transcriptomic signatures of different cell lineages that arise during development have been only partially characterized. Here we used single-cell RNA-seq to perform transcriptomic analysis of over 20,000 cells disaggregated from the trunk region of zebrafish embryos at the 30 hpf stage. Transcriptional signatures of 27 different cell types and subtypes were identified and annotated during this analysis. This dataset will be a useful resource for many researchers in the fields of developmental and cellular biology and facilitate the understanding of molecular mechanisms that regulate cell lineage choices during development.Sanjeeva MetikalaSatish Casie ChettySaulius SumanasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254024 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanjeeva Metikala Satish Casie Chetty Saulius Sumanas Single-cell transcriptome analysis of the zebrafish embryonic trunk.
description	During embryonic development, cells differentiate into a variety of distinct cell types and subtypes with diverse transcriptional profiles. To date, transcriptomic signatures of different cell lineages that arise during development have been only partially characterized. Here we used single-cell RNA-seq to perform transcriptomic analysis of over 20,000 cells disaggregated from the trunk region of zebrafish embryos at the 30 hpf stage. Transcriptional signatures of 27 different cell types and subtypes were identified and annotated during this analysis. This dataset will be a useful resource for many researchers in the fields of developmental and cellular biology and facilitate the understanding of molecular mechanisms that regulate cell lineage choices during development.
format	article
author	Sanjeeva Metikala Satish Casie Chetty Saulius Sumanas
author_facet	Sanjeeva Metikala Satish Casie Chetty Saulius Sumanas
author_sort	Sanjeeva Metikala
title	Single-cell transcriptome analysis of the zebrafish embryonic trunk.
title_short	Single-cell transcriptome analysis of the zebrafish embryonic trunk.
title_full	Single-cell transcriptome analysis of the zebrafish embryonic trunk.
title_fullStr	Single-cell transcriptome analysis of the zebrafish embryonic trunk.
title_full_unstemmed	Single-cell transcriptome analysis of the zebrafish embryonic trunk.
title_sort	single-cell transcriptome analysis of the zebrafish embryonic trunk.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2a993f33fbd341a3abfadcc10ba07687
work_keys_str_mv	AT sanjeevametikala singlecelltranscriptomeanalysisofthezebrafishembryonictrunk AT satishcasiechetty singlecelltranscriptomeanalysisofthezebrafishembryonictrunk AT sauliussumanas singlecelltranscriptomeanalysisofthezebrafishembryonictrunk
_version_	1718375051966808064

Single-cell transcriptome analysis of the zebrafish embryonic trunk.

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