Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer

Abstract Purpose The ability of the T‐cell–inflamed gene expression profile (GEP) to predict clinical outcome in esophageal cancer (EC) is unknown. This retrospective observational study assessed the prognostic value of GEP and programmed death ligand 1 (PD‐L1) expression in patients with EC treated...

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Autores principales:	Torben Steiniche, Sun Young Rha, Hyun Cheol Chung, Jeanette Baehr Georgsen, Morten Ladekarl, Marianne Nordsmark, Marie Louise Jespersen, Hyo Song Kim, Hyunki Kim, Carly Fein, Laura H. Tang, Ting Wu, Matthew J. Marton, Senaka Peter, David P. Kelsen, Geoffrey Ku
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	adenocarcinoma retrospective study squamous cell carcinoma T‐lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2a9956843ede4de294156aa54a3bb155
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spelling	oai:doaj.org-article:2a9956843ede4de294156aa54a3bb1552021-12-01T04:49:15ZPrognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer2045-763410.1002/cam4.4333https://doaj.org/article/2a9956843ede4de294156aa54a3bb1552021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4333https://doaj.org/toc/2045-7634Abstract Purpose The ability of the T‐cell–inflamed gene expression profile (GEP) to predict clinical outcome in esophageal cancer (EC) is unknown. This retrospective observational study assessed the prognostic value of GEP and programmed death ligand 1 (PD‐L1) expression in patients with EC treated in routine clinical practice. Methods Tumor samples of 294 patients from three centers in Denmark, South Korea, and the United States, collected between 2005 and 2017, were included. T‐cell–inflamed GEP score was defined as non‐low or low using a cutoff of −1.54. A combined positive score (CPS) ≥10 was defined as PD‐L1 expression positivity. Associations between overall survival (OS) and GEP status and PD‐L1 expression were explored by Cox proportional hazards models adjusting for age, sex, histology, stage, and performance status. Results Median age was 65 years; 63% of patients had adenocarcinoma (AC) and 37% had squamous cell carcinoma (SCC). Thirty‐six percent of tumors were GEP non‐low, with higher prevalence in AC (46%) than SCC (18%). Twenty‐one percent were PD‐L1–positive: 32% in South Korean samples versus 16% in non‐Asian samples and 26% in SCC versus 18% in AC. GEP scores and PD‐L1 CPS were weakly correlated (Spearman’s R = 0.363). OS was not significantly associated with GEP status (non‐low vs low; adjusted hazard ratio, 0.91 [95% CI, 0.69–1.19]) or PD‐L1 expression status. Conclusion Neither GEP nor PD‐L1 expression was a prognostic marker in Asian and non‐Asian patients with EC.Torben SteinicheSun Young RhaHyun Cheol ChungJeanette Baehr GeorgsenMorten LadekarlMarianne NordsmarkMarie Louise JespersenHyo Song KimHyunki KimCarly FeinLaura H. TangTing WuMatthew J. MartonSenaka PeterDavid P. KelsenGeoffrey KuWileyarticleadenocarcinomaretrospective studysquamous cell carcinomaT‐lymphocytesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8365-8376 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenocarcinoma retrospective study squamous cell carcinoma T‐lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	adenocarcinoma retrospective study squamous cell carcinoma T‐lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Torben Steiniche Sun Young Rha Hyun Cheol Chung Jeanette Baehr Georgsen Morten Ladekarl Marianne Nordsmark Marie Louise Jespersen Hyo Song Kim Hyunki Kim Carly Fein Laura H. Tang Ting Wu Matthew J. Marton Senaka Peter David P. Kelsen Geoffrey Ku Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer
description	Abstract Purpose The ability of the T‐cell–inflamed gene expression profile (GEP) to predict clinical outcome in esophageal cancer (EC) is unknown. This retrospective observational study assessed the prognostic value of GEP and programmed death ligand 1 (PD‐L1) expression in patients with EC treated in routine clinical practice. Methods Tumor samples of 294 patients from three centers in Denmark, South Korea, and the United States, collected between 2005 and 2017, were included. T‐cell–inflamed GEP score was defined as non‐low or low using a cutoff of −1.54. A combined positive score (CPS) ≥10 was defined as PD‐L1 expression positivity. Associations between overall survival (OS) and GEP status and PD‐L1 expression were explored by Cox proportional hazards models adjusting for age, sex, histology, stage, and performance status. Results Median age was 65 years; 63% of patients had adenocarcinoma (AC) and 37% had squamous cell carcinoma (SCC). Thirty‐six percent of tumors were GEP non‐low, with higher prevalence in AC (46%) than SCC (18%). Twenty‐one percent were PD‐L1–positive: 32% in South Korean samples versus 16% in non‐Asian samples and 26% in SCC versus 18% in AC. GEP scores and PD‐L1 CPS were weakly correlated (Spearman’s R = 0.363). OS was not significantly associated with GEP status (non‐low vs low; adjusted hazard ratio, 0.91 [95% CI, 0.69–1.19]) or PD‐L1 expression status. Conclusion Neither GEP nor PD‐L1 expression was a prognostic marker in Asian and non‐Asian patients with EC.
format	article
author	Torben Steiniche Sun Young Rha Hyun Cheol Chung Jeanette Baehr Georgsen Morten Ladekarl Marianne Nordsmark Marie Louise Jespersen Hyo Song Kim Hyunki Kim Carly Fein Laura H. Tang Ting Wu Matthew J. Marton Senaka Peter David P. Kelsen Geoffrey Ku
author_facet	Torben Steiniche Sun Young Rha Hyun Cheol Chung Jeanette Baehr Georgsen Morten Ladekarl Marianne Nordsmark Marie Louise Jespersen Hyo Song Kim Hyunki Kim Carly Fein Laura H. Tang Ting Wu Matthew J. Marton Senaka Peter David P. Kelsen Geoffrey Ku
author_sort	Torben Steiniche
title	Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer
title_short	Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer
title_full	Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer
title_fullStr	Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer
title_full_unstemmed	Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer
title_sort	prognostic significance of t‐cell–inflamed gene expression profile and pd‐l1 expression in patients with esophageal cancer
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2a9956843ede4de294156aa54a3bb155
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Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer

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